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Title: Biomarkers in sepsis
Authors: Engelen, Tjitske S. R. van
Joost Wiersinga, Willem
Scicluna, Brendon P.
Poll, Tom van der
Keywords: Septicemia -- Diagnosis
Biochemical markers -- Diagnostic use
Diagnosis -- Case studies
Issue Date: 2018
Publisher: Elsevier Inc.
Citation: van Engelen, T. S. R., Wiersinga, W. J., Scicluna, B. P., & van der Poll, T. (2018). Biomarkers in sepsis. Critical Care Clinics, 34(1), 139-152.
Abstract: A biomarker is a characteristic by which a (patho)physiologic process can be identified. Biomarkers can be of diagnostic value (to discriminate infection from noninfectious conditions or to determine the causative pathogen), of prognostic value (assigning risk profiles and predict outcome), and in the future may be of theranostic value (aid in selection and monitoring of therapy). Systems biology provides a promising tool for the discovery of novel biomarkers. Biomarkers can be the key to personalized targeted treatment in the future clinical management of sepsis.
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