University of Malta

Dr Charles Scerri
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Dr Charles Scerri

Qualification and Experience

Dr Charles Scerri B.Pharm. (Hons) M.Phil. Ph.D. MIBiol EurProBiol specializes in the behavioural, biochemical, neuropharmacological and social aspects of Alzheimer’s disease and associated dementias. He holds a Ph.D. from the University of Dundee, Scotland and currently lectures in neuropathology and neuropharmacology to various departments at the Faculty of Medicine and Surgery, University of Malta. He is a member of various international societies including the British Pharmacological Society, the Institute of Biology (UK), Laboratory Animal Science Association (UK) and the British Neuroscience Association. He is a member of the management committee on the EU Cooperation in the Field of Scientific and Technical Research (COST) Action B24 (Laboratory Animal Science and Welfare) and acted as advisor on the Preliminary Impact Assessment on the current revision of EU Council Directive 86/609/EEC and to the European Partnership for Alternative Approaches to Animal Testing. He was also selected as one of the scientific contributors to the European Children’s Future University Network (ECFUN) and scientific advisor to Alzheimer’s Europe. He has expertise in laboratory animal care, welfare and surgical techniques, animal models used in studies of neurodegenerative disorders, animal behavioural paradigms, neurogenesis and apoptosis studies, protein analysis, immunohistochemistry and immunofuorescence. He is also one of the co-founders of the Malta Dementia Society and serves as General Secretary.

Research Capacity

Current research focus on the role of the amyloid precursor protein (APP) and tau protein processing in the neuropathology of Alzheimer’s disease, the role of the nicotinic acetylcholine receptor (nAChR) in hippocampal cell proliferation and apotosis as well as dementia care and services in Malta. Other areas of interest include the use of laboratory animals for scientific research as per accepted national and European legislative procedures. Equipment for collaborative sharing include Morris water maze complete with imagining and tracking system, various apparatus used for Western blotting analysis, tissue chopper, 2 gyro rockers, temperature-controlled orbital incubator, small-animal surgical apparatus and small tissue sample cryostat.

Selected References

Scerri C., Balfour D.J.K., Breen K.C. The release of amyloid precursor protein from rat brain hippocampal slices. British Journal of Pharmacology, in press.
Scerri C., Stewart C.A., Breen K., Balfour D.J.K. (2006) The effects of chronic nicotine on spatial learning and bromodeoxyuridine incorporation in the dentate gyrus of the rat. Psychopharmacology 184 (3-4): 540-546.
Scerri C., Abela S. (2006) Prevalence of Dementia in Malta. In Dementia in Europe Yearbook 2006, Alzheimer Europe, Luxembourg, pp. 152-157.
Scerri C. (2006) Effects of chronic buproprion and nicotine administration on cell genesis and DNA fragmentation in adult rat dentate gyrus. Malta Medical Journal 18 (3): 23-27.
Scerri C. (2006) Pharmacotherapeutic approaches in the treatment of Alzheimer’s Disease. Journal of the Malta College of Pharmacy Practice 11: 8-10.
Scerri C. (2006) Would you videotape your life? The science behind memory. E-publication for the European Children’s Future University Network (ECFUN) Future Action Foundation.
Scerri C. (2005) The face of dementia.  BOLD – Journal of the International Institute of Ageing (United Nations, Malta) 15(3): 19-22.
Scerri C. (2005) Nicotine: Pharmacology and therapeutic implications in neurodegenerative and psychiatric disorders. Malta Medical Journal, 17 (4): 18-21
Abela S., Mamo J., Aquilina C., Scerri C. (2007) Estimated prevalence of dementia in the Maltese islands. Malta Medical Journal, 19 (2): 23-26

Research Funds

Dr Charles Scerri received funds from various sources including Alzheimer Europe, Alzheimer Disease International, European Federation of Neurological Associations, European Federation of Pharmaceutical Industries and Associations, European Patient Forum, University of Malta and UNESCO.

Last Updated: 12 December 2008

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