Dr Maria Cristina DAdamo

Dr Maria Cristina DAdamo

Dr Maria Cristina DAdamo

 Ph.D.

Research Support Officer IV

Faculty of Medicine & Surgery
Lab.002, Biomedical Building
Dep. of Physiology and Biochemistry
School of Medicine
  +356 2340 3692
I was awarded the Doctor’s Degree in Pharmacy (Pharm.D.) by the University of Chieti “Gabriele D’Annunzio”, the Doctor’s Degree in Neurophysiology and Electrophysiology (Ph.D.) by the University of Perugia, Faculty of Medicine and Surgery, the title of “Expert in General Physiology” and the Associate Professorship in Physiology, upon a National Scientific Qualification procedure (the latter recognition entitles awardees the recruitment in all Italian Universities as an Associate Professor of Physiology). I was a research assistant at the Institute for Pharmacological and Biomedical Research “Mario Negri” under the supervision of Prof. Maria B. Donati, visiting student at the Vollum Institute for Advanced Biomedical Research, U.S.A. (www.ohsu.edu/vollum) under the supervision of Prof. John P. Adelman and visiting scientist at the Department of Physiology & Biochemistry of the University of Malta. From 2010 to 2015, I was a Post-Doctoral Fellow at the Section of Physiology and Biochemistry of the University of Perugia, Faculty of Medicine and Surgery and, currently, I am a Research Support Officer IV at the Department of Physiology and Biochemistry of the University of Malta. I was awarded the "Alfredo Leonardi Prize for Rare Disease", the “Gustavus and Louise Pfeiffer Research Foundation Fellowship” (U.S.A.), the Principal Success of Telethon’s Research award and appointed scientific collaborator at the Tommy Fuss Center of the Boston Children's Hospital, Harvard Medical School (U.S.A.).

Current H-index:
22 (https://scholar.google.com/citations?user=l_FiN4QAAAAJ&hl=en)
21 (https://www.scopus.com/authid/detail.uri?authorId=6701790351)
  • Ion channels physiology
  • Ion channel diseases
  • Neurophysiology
  • Electrophysiology

HASAN, S., BOVE, C., SILVESTRI, G., MANTUANO, E., MODONI, A., VENEZIANO, L., MACCHIONI, L., HUNTER, T., HUNTER, G., PESSIA, M. and D'ADAMO, M.C., 2017. A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia. Scientific reports, 7(1), pp. 4583-017-03041-z.

HASAN, S.M., BALOBAID, A., GROTTESI, A., DABBAGH, O., CENCIARINI, M., RAWASHDEH, R., AL-SAGHEIR, A., BOVE, C., MACCHIONI, L., PESSIA, M., AL-OWAIN, M. and D'ADAMO, M.C., 2017. Lethal digenic mutations in the K+ channels Kir4.1 (KCNJ10) and SLACK (KCNT1) associated with severe-disabling seizures and neurodevelopmental delay. Journal of neurophysiology, , pp. jn.00284.2017.

IMBRICI, P., ALTAMURA, C., GUALANDI, F., MANGIATORDI, G.F., NERI, M., DE MARIA, G., FERLINI, A., PADOVANI, A., D'ADAMO, M.C., NICOLOTTI, O., PESSIA, M., CONTE, D., FILOSTO, M. and DESAPHY, J.F., 2017. A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions. Molecular and cellular neurosciences, 83, pp. 6-12.

ROMANI, L., OIKONOMOU, V., MORETTI, S., IANNITTI, R.G., D'ADAMO, M.C., VILLELLA, V.R., PARIANO, M., SFORNA, L., BORGHI, M., BELLET, M.M., FALLARINO, F., PALLOTTA, M.T., SERVILLO, G., FERRARI, E., PUCCETTI, P., KROEMER, G., PESSIA, M., MAIURI, L., GOLDSTEIN, A.L. and GARACI, E., 2017. Thymosin alpha1 represents a potential potent single-molecule-based therapy for cystic fibrosis. Nature medicine, 23(5), pp. 590-600.

D’ADAMO, MC, GROTTESI, A, SFORNA, L, VISENTIN, S, SERVETTINI, L, GUGLIELMI, L, MACCHIONI, L, SAREDI, S, DE NUCCIO, C, CORAZZI, L, FRANCIOLINI, F, MORA, M, CATACUZZENO, L, PESSIA, M., 2016. A calsequestrin-1 mutation associated to a skeletal mucscle disease alters Ca2+ release from sarcoplasmic reticulum. PLOS ONE, 11(5), pp. e0155516.

KAYA, N., ALSAGOB, M., D'ADAMO, M.C., AL-BAKHEET, A., HASAN, S., MUCCIOLI, M., ALMUTAIRI, F.B., ALMASS, R., ALDOSARY, M., MONIES, D., MUSTAFA, O.M., ALYOUNES, B., KENANA, R., AL-ZAHRANI, J., NAIM, E., BINHUMAID, F.S., QARI, A., ALMUTAIRI, F., MEYER, B., PLAGEMAN, T.F., PESSIA, M., COLAK, D. and AL-OWAIN, M., 2016. KCNA4 deficiency leads to a syndrome of abnormal striatum, congenital cataract and intellectual disability. Journal of medical genetics, .

SICCA, F., AMBROSINI, E., MARCHESE, M., SFORNA, L., SERVETTINI, I., VALVO, G., BRIGNONE, M.S., LANCIOTTI, A., MORO, F., GROTTESI, A., CATACUZZENO, L., BALDINI, S., HASAN, S., D'ADAMO, M.C., FRANCIOLINI, F., MOLINARI, P., SANTORELLI, F.M. and PESSIA, M., 2016. Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy. Scientific reports, 6, pp. 34325.

CATACUZZENO, L., CARAMIA, M., SFORNA, L., BELIA, S., GUGLIELMI, L., D'ADAMO, M.C., PESSIA, M. and FRANCIOLINI, F., 2015. Reconciling the discrepancies on the involvement of large-conductance Ca(2+)-activated K channels in glioblastoma cell migration. Frontiers in cellular neuroscience, 9, pp. 152.

D'ADAMO, M.C., GALLENMULLER, C., SERVETTINI, I., HARTL, E., TUCKER, S.J., ARNING, L., BISKUP, S., GROTTESI, A., GUGLIELMI, L., IMBRICI, P., BERNASCONI, P., DI GIOVANNI, G., FRANCIOLINI, F., CATACUZZENO, L., PESSIA, M. and KLOPSTOCK, T., 2015. Novel phenotype associated with a mutation in the KCNA1(Kv1.1) gene. Frontiers in physiology, 5, pp. 525.

D'ADAMO, M.C., HASAN, S., GUGLIELMI, L., SERVETTINI, I., CENCIARINI, M., CATACUZZENO, L. and FRANCIOLINI, F., 2015. New insights into the pathogenesis and therapeutics of episodic ataxia type 1. Frontiers in cellular neuroscience, 9, pp. 317.

D'ADAMO,MC. HASAN,S. GUGLIELMI,L. SERVETTINI,I. CENCIARINI,M. CATACUZZENO,L. FRANCIOLINI,F., 2015. New insights into the pathogenesis and therapeutics of episodic ataxia type 1. Frontiers in Cellular Neuroscience, 9(317),.

GUGLIELMI, L., SERVETTINI, I., CARAMIA, M., CATACUZZENO, L., FRANCIOLINI, F., D'ADAMO, M.C. and PESSIA, M., 2015. Update on the implication of potassium channels in autism: K(+) channelautism spectrum disorder. Frontiers in cellular neuroscience, 9, pp. 34.

PAROLIN SCHNEKENBERG, R., PERKINS, E.M., MILLER, J.W., DAVIES, W.I., D'ADAMO, M.C., PESSIA, M., FAWCETT, K.A., SIMS, D., GILLARD, E., HUDSPITH, K., SKEHEL, P., WILLIAMS, J., O'REGAN, M., JAYAWANT, S., JEFFERSON, R., HUGHES, S., LUSTENBERGER, A., RAGOUSSIS, J., JACKSON, M., TUCKER, S.J. and NEMETH, A.H., 2015. De novo point mutations in patients diagnosed with ataxic cerebral palsy. Brain : a journal of neurology, 138(Pt 7), pp. 1817-1832.

SFORNA, L., CENCIARINI, M., BELIA, S., D'ADAMO, M.C., PESSIA, M., FRANCIOLINI, F. and CATACUZZENO, L., 2015. The role of ion channels in the hypoxia-induced aggressiveness of glioblastoma. Frontiers in cellular neuroscience, 8, pp. 467.

SFORNA, L., D'ADAMO, M.C., SERVETTINI, I., GUGLIELMI, L., PESSIA, M., FRANCIOLINI, F. and CATACUZZENO, L., 2015. Expression and function of a CP339,818-sensitive K(+) current in a subpopulation of putative nociceptive neurons from adult mouse trigeminal ganglia. Journal of neurophysiology, 113(7), pp. 2653-2665.

AMBROSINI, E., SICCA, F., BRIGNONE, M.S., D'ADAMO, M.C., NAPOLITANO, C., SERVETTINI, I., MORO, F., RUAN, Y., GUGLIELMI, L., PIERONI, S., SERVILLO, G., LANCIOTTI, A., VALVO, G., CATACUZZENO, L., FRANCIOLINI, F., MOLINARI, P., MARCHESE, M., GROTTESI, A., GUERRINI, R., SANTORELLI, F.M., PRIORI, S. and PESSIA, M., 2014. Genetically induced dysfunctions of Kir2.1 channels: implications for short QT3 syndrome and autism-epilepsy phenotype. Human molecular genetics, 23(18), pp. 4875-4886.

CATACUZZENO, L., SFORNA, L., D'ADAMO, M.C., PESSIA, M. and FRANCIOLINI, F., 2014. A method to identify tissue cell subpopulations with distinct multi-molecular profiles from data on co-localization of two markers at a time: the case of sensory ganglia. Journal of neuroscience methods, 224, pp. 88-95.

D'ADAMO, M.C., CATACUZZENO, L., DI GIOVANNI, G., FRANCIOLINI, F. and PESSIA, M., 2013. K(+) channelepsy: progress in the neurobiology of potassium channels and epilepsy. Frontiers in cellular neuroscience, 7, pp. 134.

D'ADAMO, M.C., SERVETTINI, I., GUGLIELMI, L., DI MATTEO, V., DI MAIO, R., DI GIOVANNI, G. and PESSIA, M., 2013. 5-HT2 receptors-mediated modulation of voltage-gated K+ channels and neurophysiopathological correlates. Experimental brain research, 230(4), pp. 453-462.

BRUNETTI, O., IMBRICI, P., BOTTI, F.M., PETTOROSSI, V.E., D'ADAMO, M.C., VALENTINO, M., ZAMMIT, C., MORA, M., GIBERTINI, S., DI GIOVANNI, G., MUSCAT, R. and PESSIA, M., 2012. Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature. Neurobiology of disease, 47(3), pp. 310-321.

D'ADAMO, M.C., SHANG, L., IMBRICI, P., BROWN, S.D., PESSIA, M. and TUCKER, S.J., 2011. Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity. The Journal of biological chemistry, 286(1), pp. 192-198.

IMBRICI, P., D'ADAMO, M.C., GROTTESI, A., BISCARINI, A. and PESSIA, M., 2011. Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain. American journal of physiology.Cell physiology, 300(6), pp. C1314-22.

SICCA, F., IMBRICI, P., D'ADAMO, M.C., MORO, F., BONATTI, F., BROVEDANI, P., GROTTESI, A., GUERRINI, R., MASI, G., SANTORELLI, F.M. and PESSIA, M., 2011. Autism with seizures and intellectual disability: possible causative role of gain-of-function of the inwardly-rectifying K+ channel Kir4.1. Neurobiology of disease, 43(1), pp. 239-247.

IMBRICI, P., GROTTESI, A., D'ADAMO, M.C., MANNUCCI, R., TUCKER, S.J. and PESSIA, M., 2009. Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties. Channels (Austin, Tex.), 3(1), pp. 39-45.

IMBRICI, P., GUALANDI, F., D'ADAMO, M.C., MASIERI, M.T., CUDIA, P., DE GRANDIS, D., MANNUCCI, R., NICOLETTI, I., TUCKER, S.J., FERLINI, A. and PESSIA, M., 2008. A novel KCNA1 mutation identified in an Italian family affected by episodic ataxia type 1. Neuroscience, 157(3), pp. 577-587.

IMBRICI, P., D'ADAMO, M.C., CUSIMANO, A. and PESSIA, M., 2007. Episodic ataxia type 1 mutation F184C alters Zn2+-induced modulation of the human K+ channel Kv1.4-Kv1.1/Kvbeta1.1. American journal of physiology.Cell physiology, 292(2), pp. C778-87.

IMBRICI, P., D'ADAMO, M.C., KULLMANN, D.M. and PESSIA, M., 2006. Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2. The European journal of neuroscience, 24(11), pp. 3073-3083.

CASAMASSIMA, M., D'ADAMO, M.C., PESSIA, M. and TUCKER, S.J., 2003. Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels. The Journal of biological chemistry, 278(44), pp. 43533-43540.

IMBRICI, P., CUSIMANO, A., D'ADAMO, M.C., DE CURTIS, A. and PESSIA, M., 2003. Functional characterization of an episodic ataxia type-1 mutation occurring in the S1 segment of hKv1.1 channels. Pflugers Archiv : European journal of physiology, 446(3), pp. 373-379.

CORSARO, A., THELLUNG, S., RUSSO, C., VILLA, V., ARENA, S., D'ADAMO, M.C., PALUDI, D., ROSSI PRINCIPE, D., DAMONTE, G., BENATTI, U., ACETO, A., TAGLIAVINI, F., SCHETTINI, G. and FLORIO, T., 2002. Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein. Neurochemistry international, 41(1), pp. 55-63.

DE CURTIS, A., D'ADAMO, M.C., AMORE, C., POLISHCHUCK, R., CASTELNUOVO, A.D., DONATI, M.B. and IACOVIELLO, L., 2001. Experimental arterial thrombosis in genetically or diet induced hyperlipidemia in rats--role of vitamin K-dependent clotting factors and prevention by low-intensity oral anticoagulation. Thrombosis and haemostasis, 86(6), pp. 1440-1448.

PESSIA, M., IMBRICI, P., D'ADAMO, M.C., SALVATORE, L. and TUCKER, S.J., 2001. Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1. The Journal of physiology, 532(Pt 2), pp. 359-367.

DE CURTIS, A., D'ADAMO, M.C., AMORE, C., DONATI, M.B. and IACOVIELLO, L., 2000. Effects of dyslipidemia on t-PA release in rats. Thrombosis and haemostasis, 84(4), pp. 734-735.

IMBRICI, P., TUCKER, S.J., D'ADAMO, M.C. and PESSIA, M., 2000. Role of receptor protein tyrosine phosphatase alpha (RPTPalpha) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels. Pflugers Archiv : European journal of physiology, 441(2-3), pp. 257-262.

TUCKER, S.J., IMBRICI, P., SALVATORE, L., D'ADAMO, M.C. and PESSIA, M., 2000. pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia. The Journal of biological chemistry, 275(22), pp. 16404-16407.

D'ADAMO, M.C., IMBRICI, P., SPONCICHETTI, F. and PESSIA, M., 1999. Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 13(11), pp. 1335-1345.

SALVATORE, L., D'ADAMO, M.C., POLISHCHUK, R., SALMONA, M. and PESSIA, M., 1999. Localization and age-dependent expression of the inward rectifier K+ channel subunit Kir 5.1 in a mammalian reproductive system. FEBS letters, 449(2-3), pp. 146-152.

D'ADAMO, M.C., LIU, Z., ADELMAN, J.P., MAYLIE, J. and PESSIA, M., 1998. Episodic ataxia type-1 mutations in the hKv1.1 cytoplasmic pore region alter the gating properties of the channel. The EMBO journal, 17(5), pp. 1200-1207.

CHABIELSKA, E., KOLPAKOV, V., D'ADAMO, M.C., DE CURTIS, A., BUCZKO, W., IACOVIELLO, L. and DONATI, M.B., 1996. Morphological and hemostatic changes in rats with abdominal arterial prosthesis. Thrombosis research, 82(1), pp. 69-77.

IACOVIELLO, L., D'ADAMO, M.C., PAWLAK, K., POLISHCHUCK, R., WOLLNY, T., BUCZKO, W. and DONATI, M.B., 1996. Antithrombotic activity of dermatan sulphates, heparins and their combination in an animal model of arterial thrombosis. Thrombosis and haemostasis, 76(6), pp. 1102-1107.

IACOVIELLO, L., D'ADAMO, M.C., BUCZKO, W. and DONATI, M.B., 1995. Amiloride inhibits tissue-type plasminogen activator (t-PA) release from vascular endothelium. Thrombosis and haemostasis, 74(2), pp. 808-809.

IACOVIELLO, L., D'ADAMO, M.C., DE CURTIS, A., BUCZKO, W. and DONATI, M.B., 1995. Enhanced vascular plasminogen activator (t-PA) release by epinephrine in aged rats. Thrombosis and haemostasis, 73(5), pp. 841-844.

IACOVIELLO, L., DE CURTIS, A., D'ADAMO, M.C., AMORE, C., BUCZKO, W., DE GAETANO, G. and DONATI, M.B., 1994. Prostacyclin is required for t-PA release after venous occlusion. The American Journal of Physiology, 266(2 Pt 2), pp. H429-34.

KOLPAKOV, V., D'ADAMO, M.C., SALVATORE, L., AMORE, C., MIRONOV, A., IACOVIELLO, L. and DONATI, M.B., 1994. Neutrophil derived cathepsin G induces potentially thrombogenic changes in human endothelial cells: a scanning electron microscopy study in static and dynamic conditions. Thrombosis and haemostasis, 72(1), pp. 140-145.

D'ADAMO, M.C., 1993. Episodic Ataxia Type 1. In: R.A. PAGON, M.P. ADAM, H.H. ARDINGER, S.E. WALLACE, A. AMEMIYA, L.J.H. BEAN, T.D. BIRD, N. LEDBETTER, H.C. MEFFORD, R.J.H. SMITH and K. STEPHENS, eds, GeneReviews(R). Seattle (WA): University of Washington, Seattle. GeneReviews is a registered trademark of the University of Washington, Seattle. All rights reserved, .

IACOVIELLO, L., DE CURTIS, A., AMORE, C., D'ADAMO, M.C., BUCZKO, W., DE GAETANO, G. and DONATI, M.B., 1992. Effect of aspirin on the fibrinolytic response in perfused rat hindquarters. European journal of pharmacology, 229(1), pp. 39-44.

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