Prof. Rena Balzan

Prof. Rena Balzan

Prof. Rena Balzan

 B.Pharm.,Spec.Dip. in App.Genetics(Milan),Ph.D.(Cran.)

Senior Research Advisor

Room 145
Biomedical Sciences Building
University of Malta
Msida
  +356 2340 2336
__Biography
  • Mitochondria and oxidative stress
  • Mechanisms of apoptosis
  • Mitochondria and apoptosis
  • Aspirin and cancer

FARRUGIA, G., AZZOPARDI, M., SALIBA, C., GRECH, G., GROSS, A.S., PISTOLIC, J., BENES, V., VASSALLO, N., BORG, J., MADEO, F., EISENBERG, T. and BALZAN, R., 2019. Aspirin impairs acetyl-coenzyme A metabolism in redox-compromised yeast cells. Scientific reports, 9(1), pp. 6152; doi: 10.1038/s41598-019-39489-4.

AGIUS, A., SULTANA, R., CAMENZULI, C., CALLEJA-AGIUS, J. and BALZAN, R., 2018. An update on the genetics of pre-eclampsia. Minerva ginecologica, 70(4), pp. 465-479; doi: 10.23736/S0026-4784.17.04150-8.

CARMONA-GUTIERREZ, D., BAUER, M.A., ZIMMERMANN, A., AGUILERA, A., AUSTRIACO, N., AYSCOUGH, K., BALZAN, R., BAR-NUN, S., BARRIENTOS, A., BELENKY, P., BLONDEL, M., BRAUN, R.J., BREITENBACH, M., BURHANS, W.C., BUTTNER, S., CAVALIERI, D., CHANG, M., COOPER, K.F., CORTE-REAL, M., COSTA, V., CULLIN, C., DAWES, I., DENGJEL, J., DICKMAN, M.B., EISENBERG, T., FAHRENKROG, B., FASEL, N., FROHLICH, K.U., GARGOURI, A., GIANNATTASIO, S. and ET AL., 2018. Guidelines and recommendations on yeast cell death nomenclature. Microbial cell (Graz, Austria), 5(1), pp. 4-31; doi: 10.15698/mic2018.01.607.

AZZOPARDI, M., FARRUGIA, G. and BALZAN, R., 2017. Cell-cycle involvement in autophagy and apoptosis in yeast. Mechanisms of ageing and development, 161, pp. 211-224; doi: 10.1016/j.mad.2016.07.006.

KLIONSKY, D.J. and ET. AL., 2016. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 12(1), pp. 1-222; doi: 10.1080/15548627.2015.1100356.

FARRUGIA, G. and BALZAN, R., 2013. The Proapoptotic Effect of Traditional and Novel Nonsteroidal Anti-Inflammatory Drugs in Mammalian and Yeast Cells. Oxidative Medicine and Cellular Longevity, 2013 Article ID 504230, pp. 1-17 doi:10.1155/2013/504230.

FARRUGIA, G., BANNISTER, W., VASSALLO, N. and BALZAN, R., 2013. Aspirin-induced apoptosis of yeast cells is associated with mitochondrial superoxide radical accumulation and NAD(P)H oxidation. . FEMS Yeast Res 13, 755 - 768 doi: 10.1111/1567-1364.12075 [Epub ahead of print], .

FARRUGIA, G. and BALZAN, R., 2012. Oxidative stress and programmed cell death in yeast. Front. Oncol. 2:64. doi: 10.3389/fonc.2012.00064, , pp. 1-21.

SAPIENZA, K. AND BALZAN, R., 2008. Aspirin and Apoptosis In: FENTON, R.H. AND BURNSIDE, C.V., ed, Cell Apoptosis Research Progress New York: Nova Science Publishers, pp. 49-82.

SAPIENZA, K. AND BALZAN, R., 2008. Aspirin and Apoptosis In: P.I. QUINN, ed, Aspirin and Health Research Progress New York: Nova Science Publishers, pp. 77-110.

SAPIENZA, K., BANNISTER, W. and BALZAN, R., 2008. Mitochondrial involvement in aspirin-induced apoptosis in yeast. Microbiology, 154, pp. 2740-2747.

SAPIENZA, K. and BALZAN, R., 2007. Aspirin and Apoptosis. In: C.L. MILLWOOD, ed, New Research on Aspirin and Health. New York: Nova Science Publishers, pp. 37-70.

SHAW, G.C., COPE, J.J., LI, L., CORSON, K., HERSEY, C., ACKERMANN, G.E., GWYNN, B., LAMBERT, A.J., WINGERT, R.A., TRAVER, D., TREDE, N.S., BARUT, B.A., ZHOU, Y., MINET, E., DONOVAN, A., BROWNLIE, A., BALZAN, R., WEISS, M.J., PETERS, L.L., KAPLAN, J., ZON, L.I. and PAW, B.H., 2006. Mitoferrin is essential for erythroid iron assimilation. Nature, 440(7080), pp. 96-100.

SAPIENZA, K. and BALZAN, R., 2005. Metabolic aspects of aspirin-induced apoptosis in yeast. FEMS Yeast Res, 5(12), pp. 1207-1213.

BALZAN, R., SAPIENZA, K., GALEA, D.R., VASSALLO, N., FREY, H. and BANNISTER, W.H., 2004. Aspirin commits yeast cells to apoptosis depending on carbon source. Microbiology, 150, pp. 109-115.

SAPIENZA, K. and BALZAN, R., 2004. Is there a connection between superoxide dismutase and apoptosis? IUBMB life, 56(8), pp. 509-511.

VASSALLO, N., GALEA, D.R., BANNISTER, W.H. and BALZAN, R., 2000. Stimulation of yeast 3-phosphoglycerate kinase gene promoter by paraquat. Biochem Biophys Res Commun, 270(3), pp. 1036-1040.

AGIUS, D.R., VASSALLO, N., BANNISTER, W.H. and BALZAN, R., 1999. Studies on Oxidative Stress: Activity levels of antioxidant enzymes in copper, zinc superoxide dismutase-deficient yeast cells expressing cloned Escherichia coli iron superoxide dismutase. In: M.A. EDEAS, ed, Superoxide Dismutases: Recent Advances and Clinical Applications . Paris: Editions Mel Paris, pp. 29-33.

BALZAN, R., AGIUS, D.R. and BANNISTER, W.H., 1999. Cloned prokaryotic iron superoxide dismutase protects yeast cells against oxidative stress depending on mitochondrial location. Biochem Biophys Res Commun, 256(1), pp. 63-67.

AGIUS, D.R., BANNISTER, W.H. and BALZAN, R., 1998. Prokaryotic iron superoxide dismutase replaces cytosolic copper, zinc superoxide dismutase in protecting yeast cells against oxidative stress. Biochem Mol Biol Int, 44(1), pp. 41-49.

BALZAN, R. and BANNISTER, W.H., 1997. Oxidative Stress: A potential hazard for living organisms. Life Chem.Rep., 15, pp. 3-14.

BALZAN, R., BANNISTER, W.H., HUNTER, G.J. and BANNISTER, J.V., 1995. Escherichia coli iron superoxide dismutase targeted to the mitochondria of yeast cells protects the cells against oxidative stress. Proc Natl Acad Sci U S A, 92(10), pp. 4219-4223.

BALZAN, R., TOUATI, D., HUNTER, G.J., BANNISTER, W.H. and BANNISTER, J.V., 1994. Cloning and expression of an iron superoxide dismutase gene with a mitochondrial targeting presequence in Escherichia coli and in yeast. In: K. ASADA and T. YOSHIKAWA, eds, Frontiers of Reactive Oxygen Species in Biology and Medicine Amsterdam: Elsevier Science, pp. 275-276.

BANNISTER, J.V., BALZAN, R., HUNTER, G.J. and BANNISTER, W.H., 1994. Discrimination between iron and manganese superoxide dismutases from amino acid sequence data. In: K. ASADA and T. YOSHIKAWA, eds, Frontiers of Reactive Oxygen Species in Biology and Medicine Amsterdam: Elsevier Science, pp. 111-114.

BALZAN, R., 1978. Karyotype Instability in Tissue Cultures Derived from the Mesocotyl of Zea mays Seedlings. Caryologia, 31, pp. 75-87.

__LecturingPortfolio
__Other

https://www.um.edu.mt/_templates/staffprofiles