The Foundation Stone of the main campus at Msida (known as Tal-Qroqq) was laid on 22 September 1964 by the Rt. Hon. Duncan Sandys, the then Commonwealth Secretary. The total area of the Msida Campus is 194452 square metres
There are two other campuses: one at Valletta and the other on Malta’s sister-island, Gozo.
The Valletta Campus, which is housed in the Old University Building, dates back to the founding of the Collegium Melitense and incorporates the Aula Magna. The Valletta Campus also serves as a prestigious setting for the hosting of international conferences, seminars, short courses and summer schools. It is also the venue of the University's International Masters Programme.
The Gozo Campus (formerly known as the University of Malta Gozo Centre) was set up in 1992 with the collaboration of the Ministry for Gozo. The administration of the University of Malta Gozo Campus supports the organisation of part-time degree, diploma and short-term courses in Gozo and also caters for the needs of the increasing number of students from Gozo who study on the main campus. This campus also provides a venue for public lectures and seminars and it houses the Guesten Atmospheric Research Centre, within the Department of Physics.
19 April 2014