Prof. Gary Hunter

Prof. Gary Hunter

Prof. Gary Hunter

  B.Sc.(Hons)(Liv.),Ph.D.(Warw.)

Professor

Room 44
Biomedical Sciences Building
University of Malta
Msida
  +356 2340 2917
__Biography
  • Protein Engineering
  • Structural Molecular Biology
  • Enzymology
  • Protein Expression and Purification
  • Oxidative Stress
  • Molecular Biology
  • Reactive Oxygen Species

BONETTA, R., HUNTER, G.J., TRINH, C.H., BOROWSKI, T., FENECH, A.G., KULP, M., TABARES, L.C., UN, S. and HUNTER, T., 2021. Substitution of histidine 30 by asparagine in manganese superoxide dismutase alters biophysical properties and supports proliferation in a K562 leukemia cell line. European Biophysics Journal, 50, pp. 571-585.

HASAN, S., MEGARO, A., CENCIARINI, M., CORETTI, L., BOTTI, F.M., IMBRICI, P., STEINBUSCH, H.W.M., HUNTER, T., HUNTER, G., PESSIA, M. and D’ADAMO, M.C., 2020. Electromechanical coupling of the Kv1.1 voltage-gated K+ channel is fine-tuned by the simplest amino acid residue in the S4-S5 linker. Pflügers Archiv, 472(7), pp. 899-909.

HASAN, S., HUNTER, T., HUNTER, G., PESSIA, M. and D'ADAMO, M.C., 2018. Commentary: A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia. Frontiers in Cellular Neuroscience, 12, pp. 174.

HUNTER, T., BONETTA, R., SACCO, A., VELLA, M., SULTANA, P.M., TRINH, C.H., FADIA, H.B.R., BOROWSKI, T., GARCIA-FANDINO, R., STOCKNER, T. and HUNTER, G.J., 2018. A Single Mutation is Sufficient to Modify the Metal Selectivity and Specificity of a Eukaryotic Manganese Superoxide Dismutase to Encompass Iron. Chemistry A European Journal, 24(20), pp. 5303-5308.

HASAN, S., BOVE, C., SILVESTRI, G., MANTUANO, E., MODONI, A., VENEZIANO, L., MACCHIONI, L., HUNTER, T., HUNTER, G., PESSIA, M. and D'ADAMO, M.C., 2017. A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia. Scientific Reports, 7(1), pp. 4583.

BONETTA, R., HUNTER, G.J. and HUNTER, T., 2016. The Family of Fe/mn Superoxide Dismutase: Structure, Catalysis and Therapeutic Uses. In: N.H. PHIPPS, ed, Superoxide Dismutase (SOD): Sources, Therapeutic Uses and Health Benefits. Nova, .

HUNTER, G.J., TRINH, C.H., BONETTA, R., STEWART, E.E., CABELLI, D.E. and HUNTER, T., 2015. The structure of the Caenorhabditis elegans manganese superoxide dismutase MnSOD-3-azide complex. Protein Science, 24(11), pp. 1777-1788.

KAZARJAN, J., VAHER, M., HUNTER, T., KULP, M., HUNTER, G.J., BONETTA, R., FARRUGIA, D. and KALJURAND, M., 2015. Determination of metal content in superoxide dismutase enzymes by capillary electrophoresisdagger. J Sep Sci, 38(6), pp. 1042-1045.

HUNTER, G.J., VELLA, M., BONETTA, R., FARRUGIA, D. and HUNTER, T., 2014. The structure of protein molecules : in celebration of the International Year of Crystallography, 2014. Xjenza.

VELLA, M., HUNTER, T., FARRUGIA, C., PEARSON, A.R. and HUNTER, G., 2014. Purification and characterisation of xanthine oxidoreductases from local bovids in Malta. Advances in Enzyme Research, 2, pp. 54-58.

CASSAR, N.J. and HUNTER, G.J., 2013. Serpins : form, function and dysfunction. Xjenza, 1, pp. 51-69.

HUNTER, G.J. and THÉRÈSE HUNTER, 2013. GroESL protects superoxide dismutase (SOD)— Deficient cells against oxidative stress and is a chaperone for SOD. Health (Irvine, Calif.), 5(10), pp. 1719-1729.

SZCZEPANKIEWICZ, O., CABALEIRO-LAGO, C., TARTAGLIA, G.G., VENDRUSCOLO, M., HUNTER, T., HUNTER, G.J., NILSSON, H., THULIN, E. and LINSE, S., 2011. Interactions in the native state of monellin, which play a protective role against aggregation. Molecular Biosystems, 7(2), pp. 521-532.

TRINH, C.H., HUNTER, T., STEWART, E.E., PHILLIPS, S.E.V. and HUNTER, G.J., 2008. Purification, crystallization and X-ray structures of the two manganese superoxide dismutases from Caenorhabditis elegans. Acta Crystallographica Section F, 64(12), pp. 1110-1114.

FELICE, A.E., BORG, J., PIZZUTO, M., CASSAR, W., GALDIES, R., BEZZINA WETTINGER, S., PULIS, S., HUNTER, G.J., CARUANA, M.R., FARRUGIA, M. and SCERRI, C.A., 2007. A Review of Cis-Trans Interplay Between DNA Sequences 5′ to the Gγ- and β-Globin Genes Among Hb F-Malta-I Heterozygotes/Homozygotes and β-Thalassemia Homozygotes/Compound Heterozygotes, and the Effects of Hydroxyurea on the Hb F/F-Erythrocyte; the Need for Large Multicenter Trials. Hemoglobin, 31(2), pp. 279-288.

HUNTER, T., BANNISTER, J.V. and HUNTER, G.J., 2002. Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue. Eur J Biochem, 269(21), pp. 5137-5148.

HUNTER, T. and HUNTER, G.J., 1998. GST fusion protein expression vector for in-frame cloning and site- directed mutagenesis. BioTechniques, ol 24, Iss 2, pp. 194.

HUNTER, T. and HUNTER, G.J., 1997. Probing protein function: cloning, expression and mutagenesis of superoxide dismutases. Life_chemistry_reports, 15, pp. 65-76.

HUNTER, T., BANNISTER, W.H. and HUNTER, G.J., 1997. Cloning, expression, and characterization of two manganese superoxide dismutases from Caenorhabditis elegans. J.Biol.Chem., 272, pp. 28652-28659.

HUNTER, T., IKEBUKURO, K., BANNISTER, W.H., BANNISTER, J.V. and HUNTER, G.J., 1997. The conserved residue tyrosine 34 is essential for maximal activity of iron-superoxide dismutase from Escherichia coli. Biochemistry, ol 36, Iss 16, pp. 4925-4933.

BALZAN, R., BANNISTER, W.H., HUNTER, G.J. and BANNISTER, J.V., 1995. Escherichia coli iron superoxide dismutase targeted to the mitochondria of yeast cells protects the cells against oxidative stress. Proc Natl Acad Sci U S A, 92(10), pp. 4219-4223.

BALZAN, R., TOUATI, D., HUNTER, G.J., BANNISTER, W.H. and BANNISTER, J.V., 1994. Cloning and expression of an iron superoxide dismutase gene with a mitochondrial targeting presequence in Escherichia coli arl.d in yeast. Frontiers of reactive oxygen species in biology and medicine, 1, pp. 275-276.

DALMAS, B., HUNTER, G.J. and BANNISTER, W.H., 1994. Prediction of protein secondary structure from circular dichroism spectra using artificial neural network techniques. Biochemistry and molecular biology international, 34(1), pp. 17-26.

GIGLIO, A., HUNTER, T., BANNISTER, J.V., BANNISTER, W.H. and HUNTER, G.J., 1994. The Copper/Zinc Superoxide Dismutase Gene of Caenorhabditis Elegans. Biochemistry and Molecular Biology International, 33(1), pp. 41-44.

GIGLIO, M.P., HUNTER, T., BANNISTER, J.V., BANNISTER, W.H. and HUNTER, G.J., 1994. The manganese superoxide dismutase gene of Caenorhabditis elegans. Biochemistry and molecular biology international, 33(1), pp. 37-40.

GREENWOOD, J., HUNTER, G.J. and PERHAM, R.N., 1991. Regulation of filamentous bacteriophage length by modification of electrostatic interactions between coat protein and DNA. Journal of Molecular Biology, 217(2), pp. 223-227.

BELLAVITE, P., BAZZONI, F., CASSATELLA, M.A., HUNTER, K.J. and BANNISTER, J.V., 1990. Isolation and characterization of a cDNA clone for a novel serine-rich neutrophil protein. Biochemical and biophysical research communications, 170(2), pp. 915-922.

ROWITCH, D.H., HUNTER, G.J. and PERHAM, R.N., 1988. Variable electrostatic interaction between DNA and coat protein in filamentous bacteriophage assembly. J Mol Biol, 204(3), pp. 663-674.

HUNTER, G.J., ROWITCH, D.H. and PERHAM, R.N., 1987. Interactions between DNA and coat protein in the structure and assembly of filamentous bacteriophage fd. Nature, 327(6119), pp. 252-254.

HUNTER, G.J. and TURNOCK, G., 1985. In vivo transcription of ribosomal RNA in relation to the mitotic cycle in Physarum polycephalum. Journal of cell science, 76(1), pp. 135-143.

FITTON, L.A., HUNTER, G.J. and SWOBODA, B.E.P., 1981. The effects of cyclophosphamide and its derivatives on adenylate cyclase and protein synthesis.

  • MDS1026 - Molecular Biology and Genetics
  • MDS1038 - Cell Biology and Biochemistry
  • PHB1501 - Applied Molecular Bioscience 1: DNA Technology
  • PHB1502 - Protein Chemistry and Enzymology
  • PHB1503 - Molecules of Life
  • PHB1504 - Model Organisms in Biological Research
  • PHB2504 - Molecular Recognition and Computational Drug Design
  • PHB3501 - Applied Molecular Bioscience 3: Bioanalysis
  • PHB5050 - Biochemical Research Methods
__Other

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