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dc.contributor.authorRasic-Milutinovic, Zorica-
dc.contributor.authorPerunicic-Pekovic, Gordana-
dc.contributor.authorPljesa, Steva-
dc.contributor.authorKomadina, Ljiljana-
dc.contributor.authorGluvic, Zoran M.-
dc.contributor.authorMilic, Natasa-
dc.identifier.citationMalta Medical Journal. 2004, Vol.16(1), p. 18-22en_GB
dc.description.abstractThe aim of our study was to investigate insulin sensitivity and beta cell function in hemodialysis (HD) patients without diabetes. We hypothesized that parathyroid gland function was a determinant of insulin sensitivity and/or beta cell function. The study was a randomized, cross-sectional one and patients were divided into two groups (total 27 patients), Gp.1 being those with relative hypoparathyroidism (iPTH<200 pg/ml) ­ 9 (33.3%), Gp.2 those with hyperparathyroidism (iPTH200 pg/ml) ­ 18 (66.6%) with Gp.3 (consisting of 43 healthy subjects acting as controls). Insulin resistance and insulin secretion were calculated from fasting serum insulin and glucose concentrations by the Homeostatic Model Assessment score (HOMA IR and HOMA BETA). The value of HOMA IR (3.28±1.3 for Gp.1, 4.80±2.4 for Gp.2, 1.70±0.8 for Gp.3) as well as the glucose level (5.0±1.0mmol/l in Gp.1, 5.2±0.8mmol/ l in Gp.2, 4.6±0.4mmol/l in Gp.3) was significantly higher in HD patients than in control subjects. Excessive insulin secretion was present in HD patients (as assessed by HOMA BETA) significantly higher only in Gp.1 (p=0.02).en_GB
dc.publisherMalta Medical Journalen_GB
dc.subjectChronic renal failure -- Case studiesen_GB
dc.subjectHemodialysis -- Patientsen_GB
dc.titleImpaired Insulin sensitivity and Insulin secretion in Haemodialysis patients with and without Secondary Hyperparathyroidismen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
Appears in Collections:MMJ, Volume 16, Issue 1
MMJ, Volume 16, Issue 1

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