Prof. Giuseppe Di Giovanni

Prof. Giuseppe Di Giovanni

Prof. Giuseppe Di Giovanni



Room 142
Biomedical Sciences Building
University of Malta
  +356 2340 2776
He received his Ph.D. in Neuroscience from the University of Chieti, Italy and was a postdoctoral fellow at Yale University, USA. Previously Senior Lecturer of Human Physiology at the Faculty of Medicine and Surgery, University of Palermo, and Associate Professor at the University of Malta, from 2013 he is Professor of Human Physiology at the Medical School of the University of Malta and from 2018 Honorary Professor at Cardiff University, UK. His research focuses on understanding the pathophysiology of monoaminergic systems using electrophysiological and neurochemical approach. He has published more than 140 peer-reviewed papers, edited 7 books and 6 special issues of various journals. H-index score (47) and number of citation (more than 6361) (as of August 2021, Source = He is the Treasurer of Malta Neuroscience Network and the President of the Mediterranean Neuroscience Society (MNS). He is the Editor-in-Chief of the prestigious Journal of Neuroscience Methods by Elsevier, Amsterdam, Netherlands and the book series "The Receptors" by Springer, USA ( and serves as associate editor for the CNS Neuroscience and Therapeutics by Wiley.

Neurophysiology Lab Research Group
Dr Gabriele Deidda (Postdoc)
Ms Amber Schembri (Master Student)
Dr Jean Claude Scicluna (MD, PhD Student)
Dr Daniel Cassar (MD, PhD Student)

International Grants
R&I-2013-014, entitled ‘Closed-loop Serotonin Optogenetic Stimulation with EEG recording to Suppress Epileptic Seizures: A Therapeutic Device' € 150000 PI, GDG (AAT MT and Cardiff UK external partners). 3 years (11/2014- 10/2017)
Epilepsy Research UK grant N. P1202 entitled 'Serotonergic modulation of tonic GABA A inhibition: pathophysiological and therapeutic implications for absence seizures'. 3 years 150000£
Physiological Society UK. International Senior Research Grant. Dopamanine Neuronal ensemble recordings in freely moving rats. 7000£
PON (programmi operativi nazionali), Italy. "Polo Cyberbrain". Consortium (NEUROMED, IEMEST, Fondazione Nerone di Roma) 5,000,000 €
  • Neuroscience
  • Biological Psychiatry
  • Neurophysiology
  • Electrophysiology
  • Experimental Neurology

CHAGRAOUI, A., WHITESTONE, S., BAASSIRI, L., MANEM, J., DI GIOVANNI, G. and DE DEURWAERDÈRE, P., 2019. Neurochemical impact of the 5-HT2C receptor agonist WAY-163909 on monoamine tissue content in the rat brain. Neurochemistry international, .

COLANGELI, R., DI MAIO, R., PIERUCCI, M., DEIDDA, G., CASARRUBEA, M. and DI GIOVANNI, G., 2019. Synergistic action of CB1 and 5-HT2B receptors in preventing pilocarpine-induced status epilepticus in rats. Neurobiology of disease, .

ATON, S.J., DI GIOVANNI, G. and LERESCHE, N., 2018. Methods and models in sleep research. Journal of neuroscience methods, .

CASARRUBEA, M., MAGNUSSON, M., ANGUERA, M., JONSSON, G., CASTAÑER, M., SANTANGELO, A., PALACINO, M., AIELLO, S., FAULISI, F. and RASO, G., 2018. T-pattern detection and analysis for the discovery of hidden features of behaviour. Journal of neuroscience methods, 310, pp. 24-32.

DAVID, F., ÇARÇAK, N., FURDAN, S., ONAT, F., GOULD, T., MÉSZÁROS, Á., DI GIOVANNI, G., HERNÁNDEZ, V.M., CHAN, C.S. and LŐRINCZ, M.L., 2018. Suppression of hyperpolarization-activated cyclic nucleotide-gated channel function in thalamocortical neurons prevents genetically determined and pharmacologically induced absence seizures. Journal of Neuroscience, 38(30), pp. 6615-6627.

DELICATA, F., BOMBARDI, C., PIERUCCI, M., DI MAIO, R., DE DEURWAERDÈRE, P. and DI GIOVANNI, G., 2018. Preferential modulation of the lateral habenula activity by serotonin‐2A rather than‐2C receptors: Electrophysiological and neuroanatomical evidence. CNS neuroscience & therapeutics, 24(8), pp. 721-733.

GRANDI, L.C., KAELIN-LANG, A., ORBAN, G., SONG, W., SALVADÈ, A., STEFANI, A., DI GIOVANNI, G. and GALATI, S., 2018. Oscillatory activity in the cortex, motor thalamus and nucleus reticularis thalami in acute TTX and chronic 6-OHDA dopamine-depleted animals. Frontiers in neurology, 9.

MCCAFFERTY, C., DAVID, F., VENZI, M., LŐRINCZ, M.L., DELICATA, F., ATHERTON, Z., RECCHIA, G., ORBAN, G., LAMBERT, R.C. and DI GIOVANNI, G., 2018. Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures. Nature neuroscience, , pp. 1.

COLANGELI, R., PIERUCCI, M., BENIGNO, A., CAMPIANI, G., BUTINI, S. and DI GIOVANNI, G., 2017. The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity. Scientific reports, 7(1), pp. 11152.

DE DEURWAERDÈRE, P. and DI GIOVANNI, G., 2017. Serotonergic modulation of the activity of mesencephalic dopaminergic systems: therapeutic implications. Progress in neurobiology, 151, pp. 175-236.

RAMSAY, R.R. and DI GIOVANNI, G., 2017. Structure-Based Drug Design for Diagnosis and Treatment of Neurological Diseases. Frontiers in Pharmacology, 8, pp. 13.

RAMSAY, R.R., DE DEURWAERDÈRE, P. and DI GIOVANNI, G., 2016. Updating neuropathology and neuropharmacology of monoaminergic systems. British journal of pharmacology, 173(13), pp. 2065-2068.

ŠIMIĆ, G., BABIĆ LEKO, M., WRAY, S., HARRINGTON, C., DELALLE, I., JOVANOV-MILOŠEVIĆ, N., BAŽADONA, D., BUÉE, L., DE SILVA, R. and DI GIOVANNI, G., 2016. Tau protein hyperphosphorylation and aggregation in Alzheimer’s disease and other tauopathies, and possible neuroprotective strategies. Biomolecules, 6(1), pp. 6.

CASARRUBEA, M., JONSSON, G., FAULISI, F., SORBERA, F., DI GIOVANNI, G., BENIGNO, A., CRESCIMANNO, G. and MAGNUSSON, M., 2015. T-pattern analysis for the study of temporal structure of animal and human behavior: a comprehensive review. Journal of neuroscience methods, 239, pp. 34-46.

NAVAILLES, S., DI GIOVANNI, G. and DE DEURWAERDÈRE, P., 2015. The 5-HT4 agonist prucalopride stimulates L-DOPA-induced dopamine release in restricted brain regions of the hemiparkinsonian rat in vivo.

BORTOLATO, M., PIVAC, N., SELER, D.M., PERKOVIC, M.N., PESSIA, M. and DI GIOVANNI, G., 2013. The role of the serotonergic system at the interface of aggression and suicide. Neuroscience, 236, pp. 160-185.

BOULOUGOURIS, V., MALOGIANNIS, I., LOCKWOOD, G., ZERVAS, I. and DI GIOVANNI, G., 2013. Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy. Experimental brain research, 230(4), pp. 605-624.

CONNELLY, W.M., FYSON, S.J., ERRINGTON, A.C., MCCAFFERTY, C.P., COPE, D.W., DI GIOVANNI, G. and CRUNELLI, V., 2013. GABABreceptors regulate extrasynaptic GABAAreceptors. Journal of Neuroscience, 33(9), pp. 3780-3785.

DI GIOVANNI, G., ESPOSITO, E. and DI MATTEO, V., 2011. The 5-HT 2C Receptor Subtype Controls Central Dopaminergic Systems: Evidence from Electrophysiological and Neurochemical Studies. 5-HT2C Receptors in the Pathophysiology of CNS Disease. Humana Press, Totowa, NJ, pp. 215-247.

ERRINGTON, A.C., DI GIOVANNI, G., CRUNELLI, V. and COPE, D.W., 2011. mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus. Journal of Neuroscience, 31(23), pp. 8669-8680.

COPE, D.W., DI GIOVANNI, G., FYSON, S.J., ORBáN, G., ERRINGTON, A.C., LRINCZ, M.L., GOULD, T.M., CARTER, D.A. and CRUNELLI, V., 2009. Enhanced tonic GABAAinhibition in typical absence epilepsy. Nature medicine, 15(12), pp. 1392-1398.

PIERUCCI, M., DI MATTEO, V., BENIGNO, A., CRESCIMANNO, G., ESPOSITO, E. and DI GIOVANNI, G., 2009. The unilateral nigral lesion induces dramatic bilateral modification on rat brain monoamine neurochemistry. Annals of the New York Academy of Sciences, 1155(1), pp. 316-323.

DI GIOVANNI, G., DI MATTEO, V. and ESPOSITO, E., 2008. Serotonin-dopamine interaction: experimental evidence and therapeutic relevance. Elsevier.

DI GIOVANNI, G., DI MATTEO, V., PIERUCCI, M. and ESPOSITO, E., 2008. Serotonin–dopamine interaction: electrophysiological evidence. Progress in brain research, 172, pp. 45-71.

DIGIOVANNI, G., 2007. The basal ganglia pathophysiology: recent advances. Transworld Research Network Kerala, India.

INVERNIZZI, R., PIERUCCI, M., CALCAGNO, E., DI GIOVANNI, G., DI MATTEO, V., BENIGNO, A. and ESPOSITO, E., 2007. Selective activation of 5-HT2C receptors stimulates GABA-ergic function in the rat substantia nigra pars reticulata: a combined in vivo electrophysiological and neurochemical study. Neuroscience, 144(4), pp. 1523-1535.

DI MATTEO, V., DI GIOVANNI, G. and ESPOSITO, E., 2000. SB 242084: A selective 5‐HT2C receptor antagonist. CNS drug reviews, 6(3), pp. 195-205.

DI GIOVANNI, G., DE DEURWAERDERE, P., DI MASCIO, M., DI MATTEO, V., ESPOSITO, E. and SPAMPINATO, U., 1999. Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study. Neuroscience, 91(2), pp. 587-597.

  • DOC6029 - Getting Published: The Journal Article (Life Sciences and Medicine)
  • MDS2033 - Nervous System 2
  • PHB1504 - Model Organisms in Biological Research
Honorary Professor
Cardiff School of Biosciences,
Life Sciences Building,
Museum Avenue, Cardiff, CF10 3AX
Tel.: +44 2920875150 (direct)
+44 29 208 74986 (fax)

Journal Neuroscience Methods (Elsevier)

for the Series: The Receptors
Springer-Verlag, NY, USA

Editorial Board - CNS Neuroscience and Therapeutics (Wiley-Blackwell)

Malta Chamber of Scientists
Society for Neuroscience
International Basal Ganglia Society
Italian Society of Physiology
New York Academy of Sciences
British Physiological Society
International Society for Serotonin Research