Study-Unit Description

Study-Unit Description


TITLE Cell Therapy

LEVEL 05 - Postgraduate Modular Diploma or Degree Course



DESCRIPTION This study-unit is intended to cover all aspects of cellular biology and function, cellular sources and manipulation, and therapeutic use. Cell-based advanced therapies comprise a spectrum of complex cellular products manufactured from donated human tissues and cells or blood components and transplanted into, or administered as medicinal products to, patients for therapeutic purposes. Issues of immunological matching, the transplantation or administration procedure and potential long term clinical impact will be covered along with the regulation that covers all these activities. Ethical issues will also be addressed.

Study-unit Aims:

The study-unit aims to give detailed knowledge of cellular isolation, expansion and handling and to provide a detailed account of production of cells up to the release of products for clinical transplantation.

Learning Outcomes:

1. Knowledge & Understanding:

By the end of the study-unit the student will be able to:
- Discuss cell biology and function including knowledge of cellular sources for production of tissue components;
- Explain technologies used to isolate, expand and differentiate cellular components;
- Describe laboratory techniques and interpret data generated to analyse and sort cells;
- Discuss technologies utilized for generation of pluripotent cells and gene editing;
- Explain Immunotherapy;
- Discuss the formulation of newer cellular products including Advanced Therapy Medicinal Products and outline their use.

2. Skills:

By the end of the study-unit the student will be able to:
- Undertake research and translate new findings in the area of cellular therapy and banking;
- Analyse cells using cytometric and selection methodologies;
- Perform cryopreservation techniques;
- Run and monitor culturing techniques used to create cell banks;
- Utilise methodology for growing, differentiating and purifying cells;
- Provide advice regarding use of Advanced Therapy Medicinal Products and newer cellular preparations.

Main Text/s and any supplementary readings:

Main Texts:

- Laurence, J. and Baptista, P. (2015). Translating Regenerative Medicine to the Clinic (Advances in Translational Medicine). 1st Edition. Academic Press.
- Cell Press reviews (2015). Stem cells to Model and Treat Disease. 1st Edition. Cell Press Journals.
- Bongso, A and Lee, E. H. (2010). Stem cells from Bench to Bedside. 2nd Edition. World scientific.


- Galea, G. (2010) Essentials of Tissue banking. 1st Edition Springer.

Students will be provided with Reviews and papers from Journals.

ADDITIONAL NOTES Co-requisite Study-unit: PAT5604

STUDY-UNIT TYPE Lecture and Independent Study

Assessment Component/s Assessment Due Resit Availability Weighting
Assignment SEM1 No 10%
Assignment SEM2 No 10%
Examination (2 Hours) SEM2 Yes 80%

LECTURER/S Analisse Cassar
George Galea
Godfrey Grech
David Saliba
Pierre Schembri Wismayer
Marion Zammit Mangion

The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints.
Units not attracting a sufficient number of registrations may be withdrawn without notice.
It should be noted that all the information in the description above applies to study-units available during the academic year 2020/1. It may be subject to change in subsequent years.