Study-Unit Description

Study-Unit Description


TITLE Pharmacology C

LEVEL 03 - Years 2, 3, 4 in Modular Undergraduate Course


DEPARTMENT Clinical Pharmacology and Therapeutics

DESCRIPTION This study-unit will discuss pharmacokinetic principles in drug metabolism, clearance and drug dosage regimens. It will also look at the pharmacology and mode of action of drugs used to treat chronic neurological and respiratory disorders.

Study unit aims:

This study-unit will discuss the pharmacokinetic principles used in understanding the disposition of drugs in the body, the effects of drug metabolising enzymes, and organ clearance mechanisms as well as the estimation of drug dosage regimens. It will also look at the pharmacology and mode of action of drugs used to treat chronic neurological disorders such as epilepsy, Alzheimer’s and Parkinson’s, and the pharmacology of steroids and drugs used in respiratory disorders

Learning Outcomes:

1. Knowledge & Understanding
By the end of this study-unit, the student will be able to understand the concepts underlying:

- Multi compartment models and drug bioavailability
- Metabolism and biotransformation : Phase I and phase II reactions
- Physiological models in pharmacokinetics: Hepatic and renal clearance
- Pharmacokinetic principles in oral multiple dosage drug regimens
- Infusion drug regimens pharmacokinetics and non linear pharmacokinetics
- Basic principles in epilepsy and classification in epilepsy
- Traditional antiepileptic drugs and new antiepileptic drugs
- Pharmacokinetic principles in prescribing antiepileptic drugs
- Drugs used in other chronic neurological and movement disorders
- Parkinson's disease and Alzheimer's disease
- Inflammatory processes in asthma
- Drugs used in asthma: beta-adrenergic receptor agonists, anticholinergic agents, methylxanthines, antileukotriene agents
- Drugs used in allergies
- Glucocorticoids: models of action at cellular level, regulation of synthesis
- Structure activity relationships, adverse effects

2. Skills
By the end of this study-unit, the student will be able to:

- Apply the principles of drug metabolism and clearance in the understanding of the disposition of drugs in the body
- Apply basic pharmacological principles in the understanding of patient's drug therapy chronic neurological disorders and respiratory conditions
- Understand the patient response to drugs used in these conditions and manage therapy in these groups of patients
- Adopt a correct understanding of the correct selection of drugs in these conditions

Main texts:

- Humphrey P. Rang HP, Dale MM, Ritter JM, Flower R. Rang & Dale's Pharmacology. Churchill Livingstone. 6th Ed.
- Wecker L, Watts S, Faingold C, Dunaway G, Crespo L. Brody's Human Pharmacology. Mosby. 5th Ed.
- Rowland and Tozer. Clinical Pharmacokinetics and Pharmacodynamics. 4th Ed. Lippincott Williams and Wilkins.
- British National Formulary. Pharmaceutical Press.


- Brunton L, Lazo J, Parker K. Goodman & Gilman's The Pharmacological Basis of Therapeutics. McGraw-Hill Medical. 11th Ed.

Lecture notes

- Reid JL, Rubin PC, Walters MW. Clinical Pharmacology and Therapeutics (Lecture Notes). Blackwell. 7th Ed.
- Neal MJ. Medical Pharmacology at a Glance. Wiley-Blackwell. 6th Ed.


STUDY-UNIT TYPE Lecture and Tutorial

Assessment Component/s Assessment Due Resit Availability Weighting
Online Multiple Choice Questions Examination (2 Hours) SEM1 Yes 100%

LECTURER/S Maria A. Cordina
Roger Ellul Micallef
Claude A. Farrugia
Anthony Fenech
Janet Mifsud (Co-ord.)
Charles Scerri

The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints.
Units not attracting a sufficient number of registrations may be withdrawn without notice.
It should be noted that all the information in the description above applies to study-units available during the academic year 2020/1. It may be subject to change in subsequent years.