Study-Unit Description

Study-Unit Description


TITLE Fundamentals of Pharmacotoxicology: Principles, Classification and Toxicokinetics

LEVEL 05 - Postgraduate Modular Diploma or Degree Course


DEPARTMENT Clinical Pharmacology and Therapeutics

DESCRIPTION This study-unit will provide the background, history, tasks and scope for the study of pharmacotoxicology. This study-unit will also explain relevant aspects of the toxicokinetics and toxicodynamics of their actions. It will include a discussion on the qualitative and quantitative aspects of pharmacokinetic (LADME) processes in toxicity; drug safety in drug development; the principles of the exposure assessment, and the role of lab analysis in toxicology.

Study-unit Aims:

- To appreciate importance of principles of pharmacotoxicology as a discipline in various sectors;
- To provide basic toxicological principles, classification and concepts;
- To characterise the mechanisms of the absorption, distribution, metabolism and excretion of xenobiotics and toxicants;
- To appreciate the role of toxicology in drug development and drug safety;
- To explore the role of analytical toxicology and screening in the management of pharmacotoxicology incidents.

Learning Outcomes:

1. Knowledge & Understanding
By the end of the study-unit the student will be able to:

- Appreciate basic toxicological principles, classification and concepts;
- Explain the role of toxicokinetics;
- Critically appraise relevant aspects of current approaches to drug development and drug safety;
- Describe the classification of poisons and toxins;
- Define the principles of toxicokinetics, dose-response relationships and modulation of adverse effects with particular emphasis of these factors in drug development;
- To appreciate the role of analytical toxicology and screening and of the laboratory in dealing with toxicology incidents.

2. Skills
By the end of the study-unit the student will be able to:

- Explain various terms, principles and definitions used in pharmacotoxicology;
- Interpret the role of LADME and toxicokinetics as related to the specific mechanisms of toxic action;
- Apply this knowledge in drug development and drug safety;
- Link pharmatoxicological information and apply pharmatoxicological principles in drug dosage relationships;
- Interpret results of lab toxicological analysis in the management of patients.

Main Text/s and any supplementary readings:

Main readings

- Lewis Nelson, Robert Hoffman,Mary Ann Howland, Neal Lewin), Lewis Goldfrank, Silas W Smith Goldfrank's toxicologic emergencies. 11th edition New York McGraw Hill Medical 2019 ISBN 978-1259859618 (Health Sciences Library Reference RA1224.5 .G6 2019 )
- Curtis Klaassen, John Watkins. Casarett & Doull's Essentials of Toxicology, Third Edition. 2015. McGraw Hill ISBN 978-0071847087
- Lindsay Murray MBBS FACEM, Mark Little MBBS FACEM MPH&TM DTM&H IDHA, Ovidiu Pascu MD FACEM, Kerry Anne Hoggett MBBS GCertClinTox FACEM. Toxicology Handbook 2015 Churchill Livingston ISBN 978-0729542241(Health Sciences library RA1215 .T683 2015)

Supplementary readings

- Klaassen, Curtis D. Casarett and Doull's toxicology: the basic science of poisons. 9th edition New York McGraw-Hill Education 2019 ISBN 978-1-259-86374-5
- Yvonne Will, J. Eric McDuffie, Andrew J. Olaharski, Brandon D. Jeffy Drug Discovery Toxicology From Target Assessment to Translational Biomarkers 2016 Wiley ISBN 978-1119053330
- Kareen E Stine Thomas M Brown Principles of Toxicology 2015 CRS Press ISBN 9781466503427 (main library RA1211.S75 2015)
- Abby Calvin Textbook of Pharmacology and Toxicology. 2016 Syraword Publishing House ISBN 978-1682861912.

Journals (available in Main Library and Health Sciences Library and as e-journals subscribed by UM)

Pharmacology & toxicology
Clinical toxicology
Journal of toxicology
Comments on toxicology
Archives of toxicology
International journal of toxicology
Critical reviews in toxicology
Toxicology mechanisms and methods
Toxicology and applied pharmacology.

STUDY-UNIT TYPE Lecture and Independent Study

Assessment Component/s Assessment Due Resit Availability Weighting
Examination (2 Hours) SEM1 Yes 100%

LECTURER/S Jeffrey Bonnici
Robert Chircop
Melissa Marie Formosa
Janet Mifsud (Co-ord.)
Godwin Sammut
Mark Zammit

The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints.
Units not attracting a sufficient number of registrations may be withdrawn without notice.
It should be noted that all the information in the description above applies to study-units available during the academic year 2021/2. It may be subject to change in subsequent years.