| CODE | MLS4003 | ||||||||
| TITLE | Applied Immunohaematology | ||||||||
| UM LEVEL | 04 - Years 4, 5 in Modular UG or PG Cert Course | ||||||||
| MQF LEVEL | 6 | ||||||||
| ECTS CREDITS | 2 | ||||||||
| DEPARTMENT | Applied Biomedical Science | ||||||||
| DESCRIPTION | This is a structured lecture-based study-unit that deals with generalised as well as specialised topics and is seen as an extension to the Haematology, Transfusion Medicine and Immunology study-units in Years 2 and 3. It aims to deal with topics of a specialised nature not covered in the respective study-units throughout the earlier years. In relation to haematology, this study-unit also serves to familiarise the student with the approach to clinical and laboratory diagnosis in haematology through the use of typical clinical cases illustrating haematological disease entities. Students will have 4 one-hour lecture sessions to discuss the haematology part of this study-unit culminating in discussion of a clinical haematology case that the students will have to prepare as an assignment and on which they are marked. Content: Haematology • The use of the haematology laboratory • Abnormal haematology in the pregnant woman • Stem cell transplantation • Haematology in Systemic Disease • The approach to clinical haematology case evaluation • Clinical haematology case illustrations & assignment project Immunology • Immunity and Cancer • Laboratory investigations in Immuno-deficient states • Laboratory investigations in autoimmune disease Transfusion Medicine • The HLA system • Platelet serology • Stem cell processing • Serological problems Learning Outcomes: Haematology By the end of this study-unit, students should be able to: • Distinguish the role of the haematology laboratory in investigating and diagnosing haematological disease; • Recognise haematological diseases which may affect the pregnant patient; • Interpret clinical presentations pertaining to haematological disease and translate this data into appropriate laboratory tests and investigations to aid diagnosis and management in haematology; and • Conduct a case study report related to the subject. Immunology By the end of this study-unit the student should be able to: • Distinguish the role of the immunology laboratory in investigating and diagnosing autoimmune and immunological diseases; • Outline the different types of autoimmune disorders and the methods of identification of such disorders; and • Conduct a case study report. Transfusion Medicine By the end of this study-unit the student will should able to: • Distinguish the role of the Transfusion laboratories from Blood donor testing to serology and blood products preparation; • Define the different components that are separated from blood (e.g., red cell concentrate packs, Factor VIII, platelets and others); and • Conduct a case study report. Reading List: • Daniels G & Bromilow I. Essential Guide to Blood Group, 3rd ed. October 2013, Wiley-Blackwell. ISBN: 978-1-118-68892-2 • Harmening DM. Modern Blood Banking & Transfusion Practices, 6th ed. Philadelphia: F.A. Davis Company, 2012. ISBN-13: 978-0803626829 • Knight R. Fundamentals of Biomedical Science Blood Transfusion and Transplantation, 2013, Oxford University Press. ISBN 978-0-19-953328-2 • Klein, Harvey G. Anstee, David J.; Mollison P.L. Mollison's blood transfusion in clinical medicine. - 11th rev. ed. Blackwell Publishing 2005. ISBN-13: 978-0-632-06454-0 • Overfield J, Dawson M, Hamer D. Transfusion Science (Biomedical Science Explained Series), 2nd Edition. 2008, Scion Publishing Ltd. ISBN 978-1-904842-40-8 • Screening donated blood for transfusion-transmissible infections: recommendations. World Health Organization 2010. ISBN 978 92 4 154788 8 • Steven H Swerdlow, Elias Campo, Nancy Lee Harris, Elaine S. Jaffe, Stefano A. Pieri, Harald Stein, Jurgen Thiele, James W. Vardiman. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. ISBN 978-92-832-2431-0 (NLM Classification: WH-15) • Hoffbrand V & Moss Paul AH. Hoffbrand's Essential Haematology, 7th Edition. 2015 Wiley-Blackwell ISBN : 978-1-118-40866-7 • Pallister CJ & Watson M. Haematology, 2nd Revised edition. 2010 Scion Publishing Ltd, Bloxham. ISBN-13: 978-1-904-84239-2 • Swerdlow SJ, Campo E, Harris NL, Jaffe ES, Pieri SA, Stein H, Thiele J, Vardiman JW. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. ISBN 978-92-832-2431-0 (NLM Classification: WH-15) • Pagana KD & Pagana TJ. Mosby’s Manual of Diagnostic and Laboratory Tests, (5th Edition). Mosby, an impring of Elsevier Inc. ©2014. ISBN : 978-0-323-08949-4 Web Resources • British Committee for Standards in Haematology. GUIDELINE FOR BLOOD GROUPING AND RED CELL ANTIBODY TESTING IN PREGNANCY. Available from: http://www.bcshguidelines.com/documents/2016-02-23_BCSH_Grouping_Ab_testing_in_pregnancy.pdf • British Committee for Standards in Haematology. Guidelines for pre-transfusion compatibility procedures in blood transfusion laboratories. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3148.2012.01199.x/pdf • Serious Hazards of Transfusion website. Available at: http://www.shotuk.org/ • Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee. Guidelines for the Blood Transfusion Services in the UK 8th Edition. Available at: www.transfusionguidelines.org.uk/red-book • National Blood Transfusion Service website. Available at: http://health.gov.mt/en/nbts/Pages/home.aspx • Medicines authority website. Available at: http://medicinesauthority.gov.mt/blood • Council of Europe website. Available at: http://www.coe.int/web/portal/home |
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| STUDY-UNIT TYPE | Lecture | ||||||||
| METHOD OF ASSESSMENT |
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| LECTURER/S | Alexander Gatt Stefan Laspina David Saliba |
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The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints. Units not attracting a sufficient number of registrations may be withdrawn without notice. It should be noted that all the information in the description above applies to study-units available during the academic year 2023/4. It may be subject to change in subsequent years. |
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