| CODE | PHR1301 | ||||||||||||
| TITLE | Pharmaceutics 1 | ||||||||||||
| UM LEVEL | 01 - Year 1 in Modular Undergraduate Course | ||||||||||||
| MQF LEVEL | 5 | ||||||||||||
| ECTS CREDITS | 6 | ||||||||||||
| DEPARTMENT | Pharmacy | ||||||||||||
| DESCRIPTION | - Introduction to pharmaceutics - Weight, measures and calculation - Abbreviations and terminology in pharmaceutics - Methods of drug administration - Dosage Forms: introduction to dosage forms, formulation, packaging and labelling - Physical properties of drug substances and their efficacy and safety - Oral dosage forms: solid, liquid - External dosage forms - Medical gases - Dresses - Pharmaceutical equipment - Medical devices; catheters, thermometers, ostomy accessories, orthopaedic supports, dialysis, point-of-care devices - Alcohol and concentrated waters - Aseptic technique and clean rooms - Introduction to nuclear pharmacy - Biopharmaceutics - Pharmaceutical toxicology. Pharmaceutical Physics: - Solids, Liquids and Gases: Physical properties of the states of matter, the gas laws, the liquid crystalline state. - Phase rule: the triphasic diagram of water, rules governing diphasic and triphasic mixtures of partially miscible liquids, or liquids/solids. - Interfacial phenomena: Surface tension. - Basic principles of dissolution: Fick's laws. - Rheology: Newton's relationship between force and displacement, Newtonian and Non-Newtonian flow, thixotropy. - Application of principles of pharmaceutical physics in the areas of effect of solute concentration on viscosity, investigation of partition coefficient, buffering of pharmaceutical preparations, surface tension in pharmacy, three component phase diagrams. Powders: - Comminution: mechanisms of size reduction, grinding machines, validation of grinding. - Classification of particle size: microscope method, sedimentation method, coulter counter, sieving. - Bulk properties of powders: factors effecting packing properties, static angle of repose, dynamic angle of repose, flow meter, factors effecting flow rate, improving particle flow. - Mixing: positive, negative and neutral mixing, perfect and random mix, economic time mixtures, mixing mechanisms, types of mixer. - Segregation: factors promoting segregation, mechanisms of segregation, effect of mixing time on segregation. - Pharmaceutical calculations: expressions of concentration, triturations, calculations relation to dosage, conversions. Practical sessions in the pharmaceutical industry. Practical sessions on the preparation, reconstitution and administration of injectable medications and vaccines. Study-Unit Aims: - To introduce the student to the use of drugs to treat disease as well as to the dangers emanating from the use of these materials by society. The importance of giving the appropriate drug of the right quality at the right time will be emphasised; - To expose the students to the physicochemical principle concerned with the properties of the three state matter, and interaction between these states. The Knowledge of these properties can then be applied when discussing various aspects of formulation of pharmaceutical products; - To expose the students to the various types of dosage form and to introduce the concept and basic aspects of drug formulation; - To expose the students to the various aspect of powder behaviour during the pharmaceutical procedure such as powder particle size classification, size reduction, compressibility, mixing and segregation. Learning Outcomes: 1. Knowledge & Understanding: By the end of the study-unit the student will be able to: - Differentiate the different dosage form available; - Understand principles of powder behaviour; - Appreciate practical applicability of physico-chemical principles. 2. Skills: By the end of the study-unit the student will be able to: - Identify characteristics of excipients used in powder formulation; - Acquire mathematical skills required in pharmaceutical preparation; - Preparation and reconstitution of injectable medications and vaccines from vials and ampoules; - Safely administer vaccines by different routes at different injection sites and recognise and manage post-vaccination reactions; - Provide immunisation services in compliance with documentation requirements. Main Text/s and any supplementary readings: - Ansel HC. Pharmaceutical Calculations. USA: Lippincott, Williams and Wilkins. 2009. - Attwood D, Florence AT. Fast-track: Physical Pharmacy London: Pharmaceutical Press. 2008. - British Pharmacopoeia Commission Secretariat of the Medicines and Healthcare products Regulatory Agency. British Pharmacopoeia 2011. London: The Stationery Office. - Marriott, John; Wilson, Keith; Langley, Christopher A; Belcher, Dawn Pharmaceutical compounding and dispensing. London: Pharmaceutical Press. 2008. (Second edition). - Sinko PJ. Martin's physical pharmacy and pharmaceutical sciences. USA: Lippincott Williams and Wilkins. 2006. - Centers for Disease Control and Prevention (CDC). Epidemiology and Prevention of Vaccine-Preventable Diseases: The Pink Book Course Textbook, 14th ed.; 2021. |
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| ADDITIONAL NOTES | Please note that a pass in the Practical component is obligatory for an overall pass mark to be awarded. | ||||||||||||
| STUDY-UNIT TYPE | Lecture, Practical and Fieldwork | ||||||||||||
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| LECTURER/S | Edwina V. Brejza Maresca Attard Pizzuto Francesca Wirth |
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The University makes every effort to ensure that the published Courses Plans, Programmes of Study and Study-Unit information are complete and up-to-date at the time of publication. The University reserves the right to make changes in case errors are detected after publication.
The availability of optional units may be subject to timetabling constraints. Units not attracting a sufficient number of registrations may be withdrawn without notice. It should be noted that all the information in the description above applies to study-units available during the academic year 2023/4. It may be subject to change in subsequent years. |
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