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Title: Abnormalities of hemoglobin A₂
Authors: Vella, Francis
Keywords: Hemoglobin
Genetic disorders
Issue Date: 1969
Publisher: The St. Luke`s Hospital Gazette
Citation: Vella, F. (1969). Abnormalities of hemoglobin A₂. The St. Luke`s Hospital Gazette, 4(2), 118-124.
Abstract: Hereditary abnormalities of the A. fraction of human hemoglobin may be: (a) structural, in which a genetically determined change in the amino acid composition and sequence of either the alpha or the delta polypetide chains, results in the production of a hemoglobin A variant and (b) quantitative, in which changes in concentration in the hemoglobin A₂ fraction occur as a result of activation or repression of the genes for either the alpha or the delta chains or as a result of the replacement of the normal genes for either of these chains by structurally mutant genes. Because the beta and delta chains of human hemoglobins are linked, a number of conditions also involving the beta chain genes (delta-beta hybrid chain hemoglobins, hereditary persistence of fetal hemoglobin, the beta thalassemias) produce changes in hemoglobin A₂ concentration. Several non-hereditary states have been shown to produce quantitative changes in the hemoglobin A₂ fraction.
Appears in Collections:TSLHG, Volume 4, Issue 2
TSLHG, Volume 4, Issue 2

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