A novel metered dose inhaler with spacer for effective delivery of drugs to treat COPD

Abstract

Chronic Obstructive Pulmonary Disease has a tremendous effect on the quality of life of millions worldwide, especially elderly patients. Being that COPD is a pulmonary disease the main medication intake method is through pressured metered dose inhalers. The main problem with this medication is the lengthy required technique for inhalation, which is often the reason that these patients struggle to receive the optimal amount of medication from these inhalers. This is what motivated this project to carry out the design of a novel spacer solution that aims to optimize the medication intake by patients through inhalation technique correction. A comprehensive problem analysis, incorporating stakeholder feedback and Quality Function Deployment, identified the need for a user-friendly, lightweight, and standards-compliant device. The project employed a structured design methodology following Roozenburg and Eekels’ basic design cycle, progressing through conceptual design, solution synthesis, and simulation phases. Tools such as Function-Means Trees, Morphological Charts, and Analysis of Interconnected Decision Areas (AIDA) were used to generate and evaluate design solutions. The final design features a smart attachment compatible with existing spacer devices, integrating an audible whistle for inhalation feedback, and electronic sensors and controllers for data processing and wireless connectivity. The design prioritizes ease of use, and regulatory compliance, with attention to future scalability for smart features like real-time monitoring and app integration. Prototyping and simulation validated the design’s mechanical fit and functional performance, confirming its ability to maintain effective drug delivery while offering enhanced user feedback. The project successfully meets its objectives by providing an innovative, practical solution that addresses key challenges in COPD management, paving the way for future developments in personalized respiratory care.