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Title: Assessment of CD-105 as an Angiogenic Modulator in Odontogenic Myxomas and Dental Follicles
Authors: Carmen Gonzalez-Galvan, Maria del
Aguirre-Urizar, Jose Manuel
Bologna-Molina, Ronell
Farfan-Morales, J.E.
Gainza-Cirauqui, Maria Luisa
Marichalar-Mendia, Xabier
Mosqueda-Taylor, Adalberto
Keywords: Odontogenic tumors -- Histopathology
Mouth -- Diseases -- Diagnosis
Teeth -- Diseases -- Diagnosis
Angiogenesis Inducing Agents
Issue Date: 2016
Citation: del Carmen González-Galván, M., Aguirre-Urizar, J.M., Bologna-Molina, R., Farfán-Morales, J.E., Gainza-Cirauqui, M.L., Marichalar-Mendia, X., & Mosqueda-Taylor, A. (2016). Assessment of CD-105 as an Angiogenic Modulator in Odontogenic Myxomas and Dental Follicles. International journal of surgical pathology, 24(4), 315-319.
Abstract: Aim. Odontogenic myxoma is a benign intraosseous neoplasm of the jaws, with a locally aggressive behavior and a high recurrence rate. CD-105 is a homodimeric cell membrane glycoprotein and is a component of the TGF-β1 growth factor receptor complex that modulates angiogenesis by regulating the proliferation, differentiation and cellular migration. The aim of this study is to quantify the microvascular density of the odontogenic myxoma based on the expression of CD-105. Materials and Methods. The analysis included 18 odontogenic myxoma and 18 dental follicles as controls. A standard immunohistochemical procedure was performed with the CD-105 antibody. Five representative fields (40×) of the odontogenic myxoma and the dental follicles were selected to determine the microvascular density, which was then followed by a descriptive and comparative statistical analysis. Results. Dental follicles presented a significantly higher microvascular density compared with odontogenic myxoma (P = .001). The odontogenic myxoma smaller than 3 cm showed a greater microvascular density than those larger than 3 cm in size (P > .05), and the microvascular density was lower in large odontogenic myxomas as compared with the dental follicles (P = .003). Conclusion. A weaker expression of CD-105 in odontogenic myxoma might indicate a lower angiogenic activity, suggesting that vascular proliferation has a limited role in the growth mechanisms and in the aggressive behavior of this neoplasm.
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