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DC Field | Value | Language |
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dc.contributor.author | Navailles, Sylvia | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.contributor.author | De Deurwaerdère, Philippe | - |
dc.date.accessioned | 2017-10-13T17:19:38Z | - |
dc.date.available | 2017-10-13T17:19:38Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Navailles, S., Di Giovanni, G., & De Deurwaerdère P. (2015). The 5-HT4 agonist prucalopride stimulates L-DOPA-induced dopamine release in restricted brain regions of the hemiparkinsonian rat in vivo. CNS Neuroscience & Therapeutics. 21(9), 745-747. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22593 | - |
dc.description.abstract | The efficacy of L-3,4-dihydroxyphenylalanine (L-DOPA) in the treatment of Parkinson’s disease (PD) is impaired by anxiety or depression in some patients and iatrogenic side effects such as dyskinesia. Classical pharmacological tools such as selective serotonin reuptake inhibitors could be interesting to limit motor or nonmotor undesirable effects, but they directly target the activity of serotonergic neurons. Indeed, serotonergic (5-HT) neurons are responsible for L-DOPA-induced dopamine (DA) release and some of the inherent behavioral effects at the expense of 5-HT itself. Therefore, the difficulty emerging with the therapies associated with L-DOPA is to enhance central DA tone, without further alteration of 5-HT transmission and excessive striatal DA tone correlated to the possible appearance of dyskinesia. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Wiley-Blackwell Publishing Ltd. | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Dopamine | en_GB |
dc.subject | Levodopa | en_GB |
dc.subject | Rats as laboratory animals | en_GB |
dc.subject | Parkinson's disease | en_GB |
dc.title | The 5-HT4 agonist prucalopride stimulates L-DOPA-induced dopamine release in restricted brain regions of the hemiparkinsonian rat in vivo | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1111/cns.12436 | - |
dc.publication.title | CNS Neuroscience & Therapeutics | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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Navailles_et_al-2015-CNS_Neuroscience_&_Therapeutics.pdf Restricted Access | 157.89 kB | Adobe PDF | View/Open Request a copy |
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