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DC Field | Value | Language |
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dc.contributor.author | Sardo, Pierangelo | - |
dc.contributor.author | Ferraro, Giuseppe | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.contributor.author | Galati, Salvatore | - |
dc.contributor.author | La Grutta, Vittorio | - |
dc.date.accessioned | 2017-10-17T12:58:10Z | - |
dc.date.available | 2017-10-17T12:58:10Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Sardo, P., Ferraro, G., Di Giovanni, G., Galati , S., & La Grutta, V. (2002). Inhibition of nitric oxide synthase influences the activity of striatal neurons in the rat. Neuroscience Letters, 325(3), 179-182. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22768 | - |
dc.description.abstract | The activity of single units in the striatum of urethane-anesthetized rats was recorded before and after the systemic administration of 7-nitro-indazole (7-NI; 50 mg/kg intraperitoneally), a selective inhibitor of neuronal nitric oxide (NO) synthase. Two neuronal types were clearly distinguishable electrophysiologically, on the basis of either discharge frequency pattern or features of the individual spike waveform (spike duration, negative phase/total duration ratio, and negative phase/total amplitude ratio). Only sporadically discharging neurons (basal firing rate, <0.1 spikes/s) were influenced by 7-NI, which caused a statistically significant increase in their firing rate. In contrast, the activity of continuously discharging neurons (basal firing rate, 4–6 spikes/s) was not affected. We hypothesize that NO neurotransmission could exert a tonic inhibitory influence upon sporadically discharging striatal neurons, which are presumably striatal output neurons. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier Ireland Ltd. | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Basal ganglia | en_GB |
dc.subject | Nitric oxide | en_GB |
dc.subject | Rats as laboratory animals | en_GB |
dc.title | Inhibition of nitric oxide synthase influences the activity of striatal neurons in the rat | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/S0304-3940(02)00270-7 | - |
dc.publication.title | Neuroscience Letters | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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