Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/22768
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSardo, Pierangelo-
dc.contributor.authorFerraro, Giuseppe-
dc.contributor.authorDi Giovanni, Giuseppe-
dc.contributor.authorGalati, Salvatore-
dc.contributor.authorLa Grutta, Vittorio-
dc.date.accessioned2017-10-17T12:58:10Z-
dc.date.available2017-10-17T12:58:10Z-
dc.date.issued2002-
dc.identifier.citationSardo, P., Ferraro, G., Di Giovanni, G., Galati , S., & La Grutta, V. (2002). Inhibition of nitric oxide synthase influences the activity of striatal neurons in the rat. Neuroscience Letters, 325(3), 179-182.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/22768-
dc.description.abstractThe activity of single units in the striatum of urethane-anesthetized rats was recorded before and after the systemic administration of 7-nitro-indazole (7-NI; 50 mg/kg intraperitoneally), a selective inhibitor of neuronal nitric oxide (NO) synthase. Two neuronal types were clearly distinguishable electrophysiologically, on the basis of either discharge frequency pattern or features of the individual spike waveform (spike duration, negative phase/total duration ratio, and negative phase/total amplitude ratio). Only sporadically discharging neurons (basal firing rate, <0.1 spikes/s) were influenced by 7-NI, which caused a statistically significant increase in their firing rate. In contrast, the activity of continuously discharging neurons (basal firing rate, 4–6 spikes/s) was not affected. We hypothesize that NO neurotransmission could exert a tonic inhibitory influence upon sporadically discharging striatal neurons, which are presumably striatal output neurons.en_GB
dc.language.isoenen_GB
dc.publisherElsevier Ireland Ltd.en_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectBasal gangliaen_GB
dc.subjectNitric oxideen_GB
dc.subjectRats as laboratory animalsen_GB
dc.titleInhibition of nitric oxide synthase influences the activity of striatal neurons in the raten_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1016/S0304-3940(02)00270-7-
dc.publication.titleNeuroscience Lettersen_GB
Appears in Collections:Scholarly Works - FacM&SPB

Files in This Item:
File Description SizeFormat 
1-s2.0-S0304394002002707-main.pdf
  Restricted Access
91.94 kBAdobe PDFView/Open Request a copy


Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.