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|Title:||Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT 2A) receptors in older, healthy adults|
|Authors:||Chow, Tiffany W.|
Graff- Guerrero, Ariel
Smith, Gwenn S.
Pollock, Bruce G.
Mulsant, Benoit H.
|Keywords:||Receptor, Serotonin, 5-HT2A|
|Publisher:||BioMed Central Ltd.|
|Citation:||Chow, T. W., Mamo, D. C., Uchida, H., Graff-Guerrero, A., Houle, S., Smith, G. S., ... & Mulsant, B. H. (2009). Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT 2A) receptors in older, healthy adults. BMC Medical Imaging, 9(1), 12.|
|Abstract:||Background: Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-HT2A receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin 5HT2A receptor (5HT2AR) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring 5HT2AR availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. Results: The average difference in the binding potential (BPND) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion: We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other 5HT2AR radiotracers in younger subject samples.|
|Appears in Collections:||Scholarly Works - FacM&SPsy|
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