The pathophysiology of motor thalamus

Abstract

The thalamus is considered an important structure of sensitive pathways, and also intervenes in motor tasks. It receives multiple cortical and subcortical afferent fibers and the relations between their different nuclei are intense. After anatomic and functional study of the thalamic structure and its connections, we will analyze the different classifications and proposed subdivisions of the thalamic nuclear groups both in primates and humans. We will direct our study towards those aspects of the thalamus related to movement. The motor thalamus is described in most non-human primate studies as the thalamic region that receives subcortical afferent fibers from the basal ganglia and the cerebellum, and cortical fibers of the primary motor and pre-motor areas and these functions are also inferred to the human thalamus based on the cytoarchitectonic similarity between them. Later on, the pathological clinical aspects related to the motor thalamus are discussed. Disturbances or impairments in the coordination and course of movement, in muscular tone, and movement planning can be associated with injuries located in the motor thalamus and its connections. The research related to surgical procedures involving the thalamic structure for the treatment of impairments or disturbances of motion and movement are examined and will permit a comprehensive summary of the different mechanisms involved in the pathophysiology of the motor thalamus.