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DC Field | Value | Language |
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dc.contributor.author | Rajji, Tarek K. | - |
dc.contributor.author | Chow, Tiffany W. | - |
dc.contributor.author | Voineskos, Aristotle N. | - |
dc.contributor.author | Links, Kira A. | - |
dc.contributor.author | Miranda, Dielle | - |
dc.contributor.author | Mamo, David | - |
dc.contributor.author | Ismail, Zahinoor | - |
dc.contributor.author | Pollock, Bruce G. | - |
dc.contributor.author | Mulsant, Benoit H. | - |
dc.date.accessioned | 2017-11-13T14:08:13Z | - |
dc.date.available | 2017-11-13T14:08:13Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Rajji, T. K., Chow, T. W., Voineskos, A. N., Links, K. A., Miranda, D., Mamo, D. C., ... & Mulsant, B. H. (2012). Cholinergic pathways and cognition in patients with schizophrenia: a pilot study. Schizophrenia Research, 139(1), 46-52. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/23740 | - |
dc.description.abstract | Background: Cognitive deficits are core features in schizophrenia. Disruption in cholinergic neurotransmission has been associated with executive dysfunction in animals and humans. The objective of this study was to eval- uate the impact of compromised cholinergic pathways on executive versus non-executive cognitive functions of patients with schizophrenia. Methods: 62 patients with schizophrenia and 62 age- and sex-matched non-psychiatric control subjects (“controls”) were assessed and compared using: clinical measures, cognitive measures of global cognition, executive func- tion, and memory; and an MRI-based visual rating scale that assesses damage strategically localized within the cholinergic pathways. Results: 11 of the 62 patients with schizophrenia (17.7%) and 6 of the 62 controls (9.7%) had compromised cho- linergic pathways. These proportions were not statistically significant. Patients and controls with compromised cholinergic pathways were more impaired on measures related to executive function than patients or controls without compromised pathways. Conclusions: Patients with schizophrenia have worse executive function than controls. Compromised choliner- gic pathways appear to worsen the executive dysfunction observed in schizophrenia. If these preliminary find- ings are replicated, they could lead to the identification of a subgroup of patients with schizophrenia who could specifically benefit from interventions enhancing cholinergic neurotransmission. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier BV | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Parasympathomimetic agents | en_GB |
dc.subject | Cognition -- Data processing | en_GB |
dc.subject | Schizophrenia | en_GB |
dc.title | Cholinergic pathways and cognition in patients with schizophrenia : a pilot study | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.schres.2012.06.006 | - |
dc.publication.title | Schizophrenia Research | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPsy |
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