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https://www.um.edu.mt/library/oar/handle/123456789/23745| Title: | Long-term stability of measuring D 2 receptors in schizophrenia patients treated with antipsychotics |
| Authors: | Uchida, Hiroyuki Graff-Guerrero, Ariel Mulsant, Benoit H. Pollock, Bruce G. Mamo, David |
| Keywords: | Antipsychotic drugs Cognition -- Data processing Dopamine Schizophrenia Risperidone |
| Issue Date: | 2009 |
| Publisher: | Elsevier BV |
| Citation: | Uchida, H., Graff-Guerrero, A., Mulsant, B. H., Pollock, B. G., & Mamo, D. C. (2009). Long-term stability of measuring D 2 receptors in schizophrenia patients treated with antipsychotics. Schizophrenia Research, 109(1), 130-133. |
| Abstract: | Background While antipsychotic-free schizophrenia patients showed a high degree of within-subject variability in dopamine D2 receptor density over 6–24 months, no study has examined the long-term stability of D2 receptor measures in medicated patients. Methods Four schizophrenia patients receiving a stable dose of risperidone underwent [11C]raclopride positron emission tomography scans on two occasions 5–14 months apart. Results Plasma risperidone levels were found to be consistent between scans, and consistencies of nondisplaceable D2 binding potential and D2 occupancy were good. Conclusions The finding supports the validity of quantification of D2 receptor binding in longitudinal PET studies of medicated patients with schizophrenia. |
| URI: | https://www.um.edu.mt/library/oar//handle/123456789/23745 |
| Appears in Collections: | Scholarly Works - FacM&SPsy |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 1-s2.0-S092099640900005X-main.pdf Restricted Access | 141.11 kB | Adobe PDF | View/Open Request a copy |
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