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https://www.um.edu.mt/library/oar/handle/123456789/23922| Title: | Dopamine D 2/3 receptor availability in the striatum of antipsychotic-free older patients with schizophrenia : a [11 C]-raclopride PET study |
| Authors: | Nakajima, Shinichiro Caravaggio, Fernando Mamo, David Mulsant, Benoit H. Chung, Jun Ku Plitman, Eric Iwata, Yusuke Gerretsen, Philip Uchida, Hiroyuki Suzuki, Takefumi Mar, Wanna Wilson, Alan A. Houle, Sylvain Graff-Guerrero, Ariel |
| Keywords: | Schizophrenia Aging -- Health aspects Dopamine Receptors, Dopamine |
| Issue Date: | 2015 |
| Publisher: | Elsevier BV |
| Citation: | Nakajima, S., Caravaggio, F., Mamo, D. C., Mulsant, B. H., Chung, J. K., Plitman, E., ... & Mar, W. (2015). Dopamine D 2/3 receptor availability in the striatum of antipsychotic-free older patients with schizophrenia: a [11 C]-raclopride PET study. Schizophrenia Research, 164(1), 263-267. |
| Abstract: | Background No study has examined dopamine D2/3 receptor (D2/3R) availability in antipsychotic-free older patients with schizophrenia. Methods We included patients with schizophrenia 50 years or older who were antipsychotic-free for at least 3 months. We compared non-displaceable binding potential (BPND) of [11C]-raclopride in the caudate, putamen, ventral striatum, and globus pallidus between patients and age- and sex-matched healthy controls. Results Ten patients participated (antipsychotic-naive = 4). No differences in BPND were found between patients and controls in any ROIs (F(1, 72) = .42, p = .52). Conclusion The preliminary results suggest no differences in D2/3R availability between antipsychotic-free older patients with schizophrenia and controls. |
| URI: | https://www.um.edu.mt/library/oar//handle/123456789/23922 |
| Appears in Collections: | Scholarly Works - FacM&SPsy |
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| nihms668561.pdf Restricted Access | 344.74 kB | Adobe PDF | View/Open Request a copy |
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