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Title: Dopamine D 2/3 receptor availability in the striatum of antipsychotic-free older patients with schizophrenia : a [11 C]-raclopride PET study
Authors: Nakajima, Shinichiro
Caravaggio, Fernando
Mamo, David
Mulsant, Benoit H.
Chung, Jun Ku
Plitman, Eric
Iwata, Yusuke
Gerretsen, Philip
Uchida, Hiroyuki
Suzuki, Takefumi
Mar, Wanna
Wilson, Alan A.
Houle, Sylvain
Graff-Guerrero, Ariel
Keywords: Schizophrenia
Aging -- Health aspects
Receptors, Dopamine
Issue Date: 2015
Publisher: Elsevier BV
Citation: Nakajima, S., Caravaggio, F., Mamo, D. C., Mulsant, B. H., Chung, J. K., Plitman, E., ... & Mar, W. (2015). Dopamine D 2/3 receptor availability in the striatum of antipsychotic-free older patients with schizophrenia: a [11 C]-raclopride PET study. Schizophrenia Research, 164(1), 263-267.
Abstract: Background No study has examined dopamine D2/3 receptor (D2/3R) availability in antipsychotic-free older patients with schizophrenia. Methods We included patients with schizophrenia 50 years or older who were antipsychotic-free for at least 3 months. We compared non-displaceable binding potential (BPND) of [11C]-raclopride in the caudate, putamen, ventral striatum, and globus pallidus between patients and age- and sex-matched healthy controls. Results Ten patients participated (antipsychotic-naive = 4). No differences in BPND were found between patients and controls in any ROIs (F(1, 72) = .42, p = .52). Conclusion The preliminary results suggest no differences in D2/3R availability between antipsychotic-free older patients with schizophrenia and controls.
Appears in Collections:Scholarly Works - FacM&SPsy

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