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https://www.um.edu.mt/library/oar/handle/123456789/24967| Title: | Prevalence of the common coding variant rs2241880 of the ATG16L1 gene in Maltese Crohn’s disease patients |
| Authors: | Azzopardi, Neville Ellul, Pierre Saliba, Christian LaFerla, Godfrey Grech, Godfrey |
| Keywords: | Autophagy Crohn’s disease -- Malta |
| Issue Date: | 2012 |
| Publisher: | Malta Medical School |
| Citation: | Azzopardi, N., Ellul, P., Saliba, C., Laferla, G., & Grech, G. (2012). Prevalence of the common coding variant rs2241880 of the ATG16L1 gene in Maltese Crohn’s disease patients. VIII Malta Medical School Conference abstract book, P4.14. |
| Abstract: | In Crohn's disease the ATG16L1 (rs2241880) polymorphism affects Paneth cells and impairs autophagosome formation specifically after activation of nucleotide-binding oligomerisation domain 2 (NOD2). Studies from Europe, Australia and New Zealand have shown an increased frequency of the ATG16L1 rs2241880 SNP allele in Crohn’s disease patients versus controls while studies from Korea, Japan and East Asia revealed no positive association of this gene with Crohn’s disease. |
| URI: | https://www.um.edu.mt/library/oar//handle/123456789/24967 |
| Appears in Collections: | Scholarly Works - FacM&SPat |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Prevalence of the common coding variant rs2241880 of the Atg16l1 gene in Maltese Crohn s disease patients 2012.pdf | 124.98 kB | Adobe PDF | View/Open |
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