Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/25236
Title: Differential expression of the protein phosphatase 2 (PP2A) complex and breast cancer signature genes following suppression of mTOR signalling
Authors: Saliba, Christian
Baldacchino, Shawn
Gauci, Robert
Petroni, Vanessa
Zerafa Simler, Adrianne
Mallia, Nicola
Fenech, Anthony G.
Scerri, Christian
Grech, Godfrey
Grixti, Maria Pia
Keywords: Breast -- Cancer
Phosphoprotein phosphatases
Rapamycin
Issue Date: 2015
Publisher: Oxford University Press
Citation: Saliba, C., Baldacchino, S., Gauci, R., Grixti, M.P., Petroni, V., Zerafa Simler, A.,...Grech, G. (2015). Differential expression of the protein phosphatase 2 (pp2a) complex and breast cancer signature genes following suppression of mTOR signalling. IMPAKT 2015 Breast Cancer Conference. Brussels. Annals of Oncology 26 (Suppl 3, 54P).
Abstract: Deregulation of PP2A and its regulatory subunits is a common event in breast cancer. The cBioPortal for Cancer Genomics shows that PP2A is deregulated in 59.6% of basal breast tumours, providing a possible target for therapy. This study aims to investigate the expression of the PP2A complex components in various breast cancer cell lines and the effect of mTOR signalling suppression on breast cancer signature genes including the PP2A inhibitory subunits CIP2A, SET, SETBP1 and ANP32A.
URI: https://www.um.edu.mt/library/oar//handle/123456789/25236
Appears in Collections:Scholarly Works - FacM&SPat



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