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|Title:||Differential expression of the protein phosphatase 2 (PP2A) complex and breast cancer signature genes following suppression of mTOR signalling|
Zerafa Simler, Adrianne
Fenech, Anthony G.
Grixti, Maria Pia
|Keywords:||Breast -- Cancer|
|Publisher:||Oxford University Press|
|Citation:||Saliba, C., Baldacchino, S., Gauci, R., Grixti, M.P., Petroni, V., Zerafa Simler, A.,...Grech, G. (2015). Differential expression of the protein phosphatase 2 (pp2a) complex and breast cancer signature genes following suppression of mTOR signalling. IMPAKT 2015 Breast Cancer Conference. Brussels. Annals of Oncology 26 (Suppl 3, 54P).|
|Abstract:||Deregulation of PP2A and its regulatory subunits is a common event in breast cancer. The cBioPortal for Cancer Genomics shows that PP2A is deregulated in 59.6% of basal breast tumours, providing a possible target for therapy. This study aims to investigate the expression of the PP2A complex components in various breast cancer cell lines and the effect of mTOR signalling suppression on breast cancer signature genes including the PP2A inhibitory subunits CIP2A, SET, SETBP1 and ANP32A.|
|Appears in Collections:||Scholarly Works - FacM&SPat|
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