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Title: Systemic inflammation in COPD is not influenced by pulmonary rehabilitation
Authors: Sciriha, Anabel
Lungaro-Mifsud, Stephen
Bonello, AnneMarie
Agius, Tonio
Scerri, Josianne
Ellul, Bridget
Fenech, Anthony G.
Camilleri, Liberato
Montefort, Stephen
Keywords: Lungs -- Diseases, Obstructive
Chronic diseases -- Management
Issue Date: 2017
Publisher: Taylor & Francis
Citation: Sciriha, A., Lungaro-Mifsud, S., Bonello, A., Agius, T., Scerri, J., Ellul, B., ... & Montefort, S. (2017). Systemic inflammation in COPD is not influenced by pulmonary rehabilitation. European Journal of Physiotherapy, 19(4).
Abstract: Purpose: Pulmonary rehabilitation is known to lead to improvements in exercise tolerance, health-related quality of life and help reduce symptoms. Exercise, one of the largest components of such an intervention, although of great benefit, can increase the inflammatory response related to chronic obstructive pulmonary disease, depending on intensity and duration. Through this study, the effects of a 12week, high-intensity PR programme on COPD inflammatory-related markers were investigated. Materials and methods: This study is a longitudinal, observational type of study. Sixty COPD patients were enrolled, 49 of which completed the programme. A 2-h high-intensity PR programme was delivered, twice weekly for 12 weeks. The following markers were assessed at baseline, 4, 8 and 12 weeks through rehabilitation – C-reactive protein, erythrocyte sedimentation rate, neutrophil, eosinophil counts, complete blood count, six-minute walk test and St. George’s Respiratory Questionnaire. Serum amyloid A levels were assessed at baseline, week 8 and 12 and exhaled NO at baseline and upon completion of the programme. Results: This 12-week PR programme resulted in no changes in the inflammatory markers but resulted in significant improvements in both the 6MW distance and health quality of life. Conclusions: Beneficial effects on functional and HRQoL measures resulted, which, however, appear unrelated to changes in the systemic inflammatory markers.
ISSN: 21679169
Appears in Collections:Scholarly Works - FacM&SCPT

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