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|Title:||(-) Deprenyl induces activities of both superoxide dismutase (SOD) and catalase but not of glutathione peroxidase (GSH Px) in the striatum of male rats|
Carrillo, Maria Cristina
Ivy, Gwen O.
Free radicals (Chemistry)
|Publisher:||University of Malta. Department of Pharmacy|
|Citation:||Kitani, K., Carrillo, M.C., Kanai, S., Nokubo, M., & Ivy, G.O. (1991). (-) Deprenyl induces activities of both superoxide dismutase (SOD) and catalase but not of glutathione peroxidase (GSH Px) in the striatum of male rats. Proceedings of the First Symposium on Drugs in the Elderly in Malta held in March 1991, Malta. 14-23.|
|Abstract:||Daily s.c. injection of (−)deprenyl (2.0 mg/kg/day) for three weeks in young male Fischer-344 rats (6 months old) caused a threefold increase in SOD activities (U/mg) in the striatum compared with the value in saline-injected control rats. Furthermore, the activity of catalase (U/mg) (but not of GSH Px) was also significantly increased by deprenyl treatment. Subsequent studies also confirmed that the drug is effective in young and old female rats as well. However, the optimal dose was 10 fold lower in young female rats than in male rats. Furthermore aging reduced the sex difference in optimal drug dosage. The results confirm the original finding by Knoll on SOD activity but also provide evidence that catalase activity is significantly enhanced by this drug which is at variance with the work of Knoll. The radical scavenging effect of SOD is effective only when it is accompanied by activities of catalase and/ or GSH Px, since SOD generates hydrogen peroxide which is more toxic than oxygen radicals. For this reason the present findings more logically support the original contention of Knoll that increased SOD activity may be beneficial in preventing possible tissue damage caused by free radicals during the aging process. Furthermore, future studies on deprenyl must be carefully performed, taking sex and age differences into account regarding the optimal dose of the drug.|
|Appears in Collections:||Proceedings of the First Symposium on Drugs in the Elderly in Malta held in March 1991|
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