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Title: Determination of acetylator phenotype with respect to isoniazid in Malta
Authors: Vella, John Paul
Keywords: Acetylator status (Pharmacology)
Tuberculosis -- Treatment
Isoniazid -- Metabolism
Issue Date: 1992
Publisher: University of Malta. Department of Pharmacy
Citation: Vella, J. P. (1992). Determination of acetylator phenotype with respect to isoniazid in Malta. In A. Serracino-Inglott (Ed.), Pharmacy Final Year Students 1992 Project Abstracts, Vol. 2, (pp. 609-616). University of Malta. Department of Pharmacy.
Abstract: The studies carried out involved isoniazid, an important chemotherapeutic agent in anti-tuberculous treatment. Two main aims were identified, and both were concerned with the existence of fast and slow acetylators (inactivators) of isoniazid. The first aim was the determination of the distribution ratio of fast and slow metabolisers in a sample of Maltese volunteers, this quite possibly being the first time any such attempt was made locally. A secondary design of the first aim was the possible correlation of factors, other than genetic ones, with the acetylator phenotype. The second aim was an attempt at reasserting certain genetic principles with regards to the isoniazid acetylator phenotype, in a Maltese context. These principles were established in 1960 by Evans et al and stated that the isoniazid acetylator phenotype is determined by a single pair of genes located on an autosomal chromosome, with the gene for slow acetylation recessive to that for fast acetylation.
Appears in Collections:Pharmacy final year students 1992 project abstracts : volume two

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