Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/43280
Title: Changes in epithelial cell lysosomes during experimental oral carcinogenesis
Authors: Smith, C.J.
Camilleri, George E.
Keywords: Lysosomes
Carcinogenesis
Issue Date: 1964
Citation: Smith, C.J., & Camilleri, G.E.. (1964). Changes in epithelial cell lysosomes during experimental oral carcinogenesis. Nature, Vol. 201, no. 4918, 512-514.
Abstract: The general concept of lysosomes as separate cytoplasmic organelles was originated by de Duve1 in 1955, when he also demonstrated that acid phosphatase is characteristically present in these structures. Other workers have determined the cytological location of lysosomes by applying histochemical techniques for acid phosphatase to specially prepared tissue sections. This commumication describes changes in the lysosomes of malignant epithelial cells, as shown by staining fresh frozen cryostat sections and exfoliated ¬∑cell smears for acid phosphatase. The malignant tumours used in this experiment were produced in hamster cheek pouches in response to repeated applications of a chemical carcinogen, in a manner similar to that first described by Salley.
URI: https://www.um.edu.mt/library/oar//handle/123456789/43280
Appears in Collections:Melitensia Works - ERCSciNHB

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