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https://www.um.edu.mt/library/oar/handle/123456789/43280| Title: | Changes in epithelial cell lysosomes during experimental oral carcinogenesis |
| Authors: | Smith, C.J. Camilleri, George E. |
| Keywords: | Lysosomes Carcinogenesis |
| Issue Date: | 1964 |
| Citation: | Smith, C.J., & Camilleri, G.E.. (1964). Changes in epithelial cell lysosomes during experimental oral carcinogenesis. Nature, Vol. 201, no. 4918, 512-514. |
| Abstract: | The general concept of lysosomes as separate cytoplasmic organelles was originated by de Duve1 in 1955, when he also demonstrated that acid phosphatase is characteristically present in these structures. Other workers have determined the cytological location of lysosomes by applying histochemical techniques for acid phosphatase to specially prepared tissue sections. This commumication describes changes in the lysosomes of malignant epithelial cells, as shown by staining fresh frozen cryostat sections and exfoliated ·cell smears for acid phosphatase. The malignant tumours used in this experiment were produced in hamster cheek pouches in response to repeated applications of a chemical carcinogen, in a manner similar to that first described by Salley. |
| URI: | https://www.um.edu.mt/library/oar//handle/123456789/43280 |
| Appears in Collections: | Melitensia Works - ERCSciNHB |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Changes in epithelial cell lysosomes during experimental oral carcinogenesis (2).PDF Restricted Access | 1.23 MB | Adobe PDF | View/Open Request a copy |
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