Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/476
Title: | Multiple Myeloma : an update on disease biology and therapy |
Authors: | Dingli, David Cook, Rachel J. |
Keywords: | Multiple myeloma -- Treatment Multiple myeloma -- Pathogenesis Tumor microenvironment |
Issue Date: | 2004 |
Publisher: | Malta Medical Journal |
Citation: | Malta Medical Journal. 2004, Vol.16(1), p. 8-12 |
Abstract: | Multiple myeloma is a malignancy of immunoglobulin producing plasma cells. Clinical features include bone pain due to lytic bone lesions or pathological fractures, anemia, symptomatic hypercalcemia, renal insufficiency, recurrent infections and amyloidosis. In the last few years, there have been considerable advances in the understanding of the biology of this disease. While multiple myeloma is biologically diverse, several oncogenes are activated in this illness. In addition, the role of the bone marrow microenvironment to support the growth and survival of the malignant cells has been well described. In this review, we discuss recent developments in the molecular pathogenesis of myeloma. These recent observations are being translated into novel therapeutic approaches that target both the tumor cell as well as the stroma. Current therapeutic strategies are discussed. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/476 |
Appears in Collections: | MMJ, Volume 16, Issue 1 MMJ, Volume 16, Issue 1 |
Files in This Item:
File | Description | Size | Format | |
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2004.Vol16.Issue1.A1.pdf | Multiple Myeloma: an update on disease biology and therapy | 81.22 kB | Adobe PDF | View/Open |
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