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dc.contributor.authorAbela, Alexia-Giovanna-
dc.contributor.authorFava, Stephen-
dc.identifier.citationAbela, A. G., & Fava, S. (2019). Incidence of type 1 diabetes and distance from the sea: a descriptive epidemiological study. Journal of Diabetes, 11(5), 345-347.en_GB
dc.description.abstractBackground: Increasingly, environmental factors are being shown to play a role in the etiology of type 1 diabetes (T1D). One geographical feature that exerts a major effect on climate but whose relationship with T1D incidence has not been studied is distance from the sea. This study investigated any possible relationship between distance from the sea and the incidence of T1D. Methods: Spearman correlation analysis was performed to investigate the relationship between the incidence of T1D (determined using data from the DiaMond Project) and distance from the sea. This was followed by multivariate analyses to adjust for potential cofounders. Results: A significant negative association was found between T1D incidence and shortest distance from sea (r = −0.251, P = 0.01235), mean hours of sunshine (r = −0.325, P = 0.002), and mean temperature (r = −0.224, P = 0.046), and a positive association was found between T1D incidence and latitude (r = 0.434, P = 0.0001). Multivariate analysis (generalized linear model) showed that both distance from the sea and latitude were independently associated with the incidence of T1D. The association of distance from sea and the incidence of T1D remained significant even after adjusting for mean temperature (P = 0.002) and mean hours of sunshine (P = 0.005). Conclusions: The data show that there is a negative correlation between distance from the sea and the incidence of T1D, which was independent of latitude, mean temperature, and mean hours of sunshine. This suggests that environmental factors associated with climatic conditions may influence the risk of T1D.en_GB
dc.subjectDiabetes -- Environmental aspectsen_GB
dc.subjectDiabetes -- Climatic factorsen_GB
dc.subjectDiabetes Mellitus, Type 1en_GB
dc.subjectDiabetes -- Epidemiology -- Researchen_GB
dc.subjectDiseases -- Causes and theories of causationen_GB
dc.titleIncidence of type 1 diabetes and distance from the sea : a descriptive epidemiological studyen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.publication.titleJournal of Diabetesen_GB
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