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dc.contributor.authorBajada, Claude J.-
dc.contributor.authorSchreiber, Jan-
dc.contributor.authorCaspers, Svenja-
dc.identifier.citationBajada, C. J., Schreiber, J., & Caspers, S. (2019). Fiber length profiling: A novel approach to structural brain organization. Neuroimage, 186, 164-173.en_GB
dc.description.abstractThere has been a recent increased interest in the structural connectivity of the cortex. However, an important feature of connectivity remains relatively unexplored; tract length. In this article, we develop an approach to characterize fiber length distributions across the human cerebral cortex. We used data from 76 participants of the Adult WU-Minn Human Connectome Project using probabilistic tractography. We found that connections of different lengths are not evenly distributed across the cortex. They form patterns where certain areas have a high density of fibers of a specific length while other areas have very low density. To assess the relevance of these new maps in relation to established characteristics, we compared them to structural indices such as cortical myelin content and cortical thickness. Additionally, we assessed their relation to resting state network organization. We noted that areas with very short fibers have relatively more myelin and lower cortical thickness while the pattern is inverted for longer fibers. Furthermore, the cortical fiber length distributions produce specific correlation patterns with functional resting state networks. Specifically, we find evidence that as resting state networks increase in complexity, their length profiles change. The functionally more complex networks correlate with maps of varying lengths while primary networks have more restricted correlations. We posit that these maps are a novel way of differentiating between ‘local modules’ that have restricted connections to ‘neighboring’ areas and ‘functional integrators’ that have more far reaching connectivity.en_GB
dc.publisherElsevier Ltd.en_GB
dc.subjectWhite matteren_GB
dc.subjectPrefrontal cortexen_GB
dc.subjectCognitive neuroscienceen_GB
dc.subjectOptical data processingen_GB
dc.titleFiber length profiling : a novel approach to structural brain organizationen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
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