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dc.contributor.authorMuscat Baron, Yves-
dc.contributor.authorBrincat, Mark P.-
dc.contributor.authorGalea, Raymond-
dc.contributor.authorCalleja, Neville-
dc.date.accessioned2020-09-18T08:35:09Z-
dc.date.available2020-09-18T08:35:09Z-
dc.date.issued2005-
dc.identifier.citationMuscat Baron. Y., Brincat, M. P., Galea, R., & Calleja, N. (2005). Intervertebral disc height in treated and untreated overweight post-menopausal women. Human Reproduction, 20(12), 3566-3570.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/60618-
dc.description.abstractBACKGROUND: The effect of the menopause and HRT on the intervertebral discs has not been investigated. METHODS: One hundred women were recruited, comprising of 44 post-menopausal women on HRT, 33 untreated post-menopausal women and 23 pre-menopausal women. The height of the intervertebral discs between the 12th thoracic vertebra and the 3rd lumbar vertebra was measured by utilizing the bone densitometer height cursors. RESULTS: The untreated menopausal group of women had the lowest total disc height (D1–D3: 1.95 0.31 cm). This was significantly lower than the pre-menopausal group D1–D3: 2.16 0.24 cm) and the hormone-treated group (2.2 0.26 cm) (P > 0.02). The 2nd intervertebral disc consistently maintained a significant difference between the untreated menopausal group (D2: 0.63 0.13) and the other two groups (pre-menopausal group (D2: 0.72 0.09 cm) and treated menopausal group (D2: 0.73 0.12 cm) (P > 0.02). CONCLUSIONS: Estrogen-replete women appear to maintain higher intervertebral discs compared to untreated post-menopausal women. The estrogenic milieu may be relevant because of the significant impact it has on the hydrophilic glycosaminoglycans, the water content, collagen and elastin of the intervertebral discs. The maintenance of adequate disc height may allow the intervertebral discs to retain their discoid shape and viscoelastic function, containing vertical forces which may threaten spinal architecture leading to vertebral body compression fractures.en_GB
dc.language.isoenen_GB
dc.publisherOxford University Pressen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectEstrogenen_GB
dc.subjectExtracellular matrixen_GB
dc.subjectIntervertebral disken_GB
dc.subjectMenopauseen_GB
dc.subjectOsteoporosisen_GB
dc.titleIntervertebral disc height in treated and untreated overweight post-menopausal womenen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1093/humrep/dei251-
dc.publication.titleHuman Reproductionen_GB
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