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https://www.um.edu.mt/library/oar/handle/123456789/88535| Title: | Synthesis of minoxidil conjugates and their evaluation as HL-60 differentiation agents |
| Authors: | Stoica, Sonia Magoulas, George E. Antoniou, Antonia I. Suleiman, Sherif Cassar, Analisse Vassallo Gatt, Lucienne Papaioannou, Dionissios Athanassopoulos, Constantinos M. Schembri-Wismayer, Pierre |
| Keywords: | Minoxidil Conjugation (Biology) Polyamines |
| Issue Date: | 2016 |
| Publisher: | Elsevier |
| Citation: | Stoica, S., Magoulas, G. E., Antoniou, A. I., Suleiman, S., Cassar, A., Gatt, L., ... & Schembri-Wismayer, P. (2016). Synthesis of minoxidil conjugates and their evaluation as HL-60 differentiation agents. Bioorganic & Medicinal Chemistry Letters, 26(4), 1145-1150. |
| Abstract: | Activation of minoxidil (MNX) with N,N′-carbonyldiimidazole and coupling with natural polyamines (PAs) and commercially available aliphatic or aromatic amines provided a series of new conjugates which were evaluated for their ability to induce differentiation to HL-60 acute myeloid leukemia cancer cells, using a modified NBTZ reduction test. Although neither MNX nor 4,4′-methylenedianiline (MDA) or 2,7-diaminofluorene (DAF), alone or in combination, had any effect, the MNX-spermine (SPM) conjugate (11) and the conjugates 7 and 8 of MNX with MDA and DAF exhibited a differentiation-inducing effect at a concentration of 10 μM without being toxic on proliferating human peripheral blood mononuclear cells. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/88535 |
| Appears in Collections: | Scholarly Works - SchFS |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Synthesis of minoxidil conjugates and their evaluation.pdf Restricted Access | 1.89 MB | Adobe PDF | View/Open Request a copy |
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