Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/98495
Title: Breaking the silence : the interplay between transcription factors and DNA methylation
Other Titles: Methylation
Authors: Baron, Byron
Keywords: Methylation
DNA
Cell biology
Epigenetics
Developmental biology
Human genome
Issue Date: 2012
Publisher: Intechopen
Citation: Baron, B. (2014). Breaking the silence : The interplay between transcription factors and DNA methylation. In A .Dric (Ed.), Methylation (pp.1-26). Intechopen.
Abstract: DNA methylation is best known for its role in gene silencing through a methyl group (CH3) being added to the 5' carbon of cytosine bases (giving 5-methylcytosine) in the promoters of genes leading to supression of transcription. De novo methylation, which involves the addition of a methyl group to unmodified DNA, is described as an epigenetic change because it is a chemical modification to DNA not a change brought about by a DNA mutation. Unlike mutations, methylation changes are potentially reversible. Epigenetic changes also include changes to DNA-associated molecules such as histone modifications, chromatin-remodelling complexes and other small non-coding RNAs including miRNAs and siRNAs. These changes have key roles in imprinting (gene-ex‐ pression dependent on parental origin), X chromosome inactivation and heterochromatin formation among others [3-5].
URI: https://www.um.edu.mt/library/oar/handle/123456789/98495
Appears in Collections:Scholarly Works - CenMMB



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