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DC Field | Value | Language |
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dc.contributor.author | Agius, Rachel | - |
dc.contributor.author | Pace, Nikolai Paul | - |
dc.contributor.author | Fava, Stephen | - |
dc.date.accessioned | 2022-09-12T06:21:15Z | - |
dc.date.available | 2022-09-12T06:21:15Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Agius, R., Pace, N. P., & Fava, S. (2022). Reduced leukocyte mitochondrial copy number in metabolic syndrome and metabolically healthy obesity. Frontiers in endocrinology, 13. doi: 10.3389/fendo.2022.886957 | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/101644 | - |
dc.description.abstract | Objective: This study aimed to investigate the associations between peripheral blood leukocyte mitochondrial copy number, metabolic syndrome, and adiposity-related body composition phenotypes in a high prevalence population. Methods: A single center cross-sectional study was conducted, consisting of 521 middle-aged subjects of Maltese-Caucasian ethnicity. Participants were stratified according to the presence of metabolic syndrome and different metabolic health definitions based on NCEP-ATP III criteria. Relative leukocyte mitochondrial DNA copy number was determined by quantitative polymerase chain reaction and corrected for leukocyte and platelet count. The associations between mitochondrial copy number and metabolic syndrome components was evaluated and adjusted for age and gender. Results: Significant negative correlations between mtDNA copy number and BMI, waist circumference, triglyceride levels, fasting plasma glucose, HbA1c, HOMA-IR and hsCRP were observed, along with a positive correlation with HDL-C levels. Mitochondrial copy number was lower in individuals with metabolic syndrome. When compared to metabolically healthy normal weight subjects, a reduction in mtDNA copy number was observed in both the metabolically healthy and unhealthy obese categories. Conclusion: Our data supports the association between reduced leukocyte mtDNA copy number, obesity, and metabolic syndrome. This investigation expands on the spectrum of associations between mtDNA copy number and metabolic phenotypes in different populations and underpins the role of mitochondrial dysfunction in the development and progression of metabolic syndrome and its components. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Research Foundation | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Mitochondrial DNA | en_GB |
dc.subject | Obesity -- Case studies | en_GB |
dc.subject | Metabolic syndrome -- Diagnosis | en_GB |
dc.subject | Insulin resistance | en_GB |
dc.subject | Metabolism -- Disorders -- Diagnosis | en_GB |
dc.title | Reduced leukocyte mitochondrial copy number in metabolic syndrome and metabolically healthy obesity | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.3389/fendo.2022.886957 | - |
dc.publication.title | Frontiers in endocrinology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SAna |
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File | Description | Size | Format | |
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Reduced_leukocyte_mitochondrial_copy_number_in_metabolic_syndrome_and_metabolically_healthy_obesity.pdf | 1.23 MB | Adobe PDF | View/Open |
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