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Title: | FTY720 restores the activity of the phosphatase PP2A in specific breast cancer cell lines |
Other Titles: | 251 FTY720 restores the activity of the phosphatase PP2A in specific breast cancer cell lines |
Authors: | Saliba, C. Baldacchino, S. Borg, N. Ellul, B. Scerri, C. Grech, Godfrey |
Keywords: | Breast -- Cancer -- Treatment Phosphoprotein phosphatases -- Inhibitors Fingolimod Hydrochloride |
Issue Date: | 2014 |
Publisher: | Elsevier |
Citation: | Saliba, C., Baldacchino, S., Borg, N., Ellui, B., Scerri, C., & Grech, G. (2014). FTY720 restores the activity of the phosphatase PP2A in specific breast cancer cell lines. European Journal of Cancer, 50, S116-S116. |
Abstract: | Triple negative breast cancer (TNBC) patients derive little benefit from target-specific therapies due to lack of the favourable prognostic targets oestrogen/progesterone receptor and human epidermal growth factor receptor type 2 (HER2). The cBioPortal for Cancer Genomics shows that the protein phosphatase 2 (PP2A) is deregulated in 59.6% of basal breast tumours. Patients exhibit either homozygous deletion or underexpression of PP2A, but also overexpression of PP2A inhibitors namely CIP2A, SET, SETBP1 or IGBP1. FTY720, a pharmacological activator of PP2A may help restore its activity, ultimately reversing the constitutive proliferation. In this study we tested the efficacy of FTY720 on a number of breast cancer cell lines. [Excerpt] |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/104183 |
Appears in Collections: | Scholarly Works - FacM&SPat |
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