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https://www.um.edu.mt/library/oar/handle/123456789/104381| Title: | The regulation of mRNA translation controls the balance between expansion and differentiation of erythroid progenitors |
| Authors: | Grech, Godfrey Balzquez-Domingo, Montserrat Kolbus, Andreas Bakker, Walbert Dolznig, Helmut Lowenberg, Bob Beug, Hartmut Lindern, Marieke von |
| Keywords: | Erythroid precursor cells Proteins -- Synthesis Cell differentiation -- Molecular aspects Erythrocytes -- Physiology Dexamethasone |
| Issue Date: | 2004 |
| Publisher: | American Society of Hematology |
| Citation: | Grech, G., Balzquez-Domingo, M., Kolbus, A., Bakker, W., Dolznig, H., Lowenberg, B.,...von Lindern, M. (2004). The Regulation of mRNA Translation Controls the Balance between Expansion and Differentiation of Erythroid Progenitors. Blood, 104(11), 462. |
| Abstract: | Erythroid progenitors can be expanded in vitro in the presence of erythropoietin (Epo), stem cell factor (SCF) and dexamethasone, while they differentiate to enucleated erythrocytes in presence of Epo only. Our study aims to identify (i) signaling pathways that control expansion of erythroid progenitors and (ii) genes regulated by these signaling pathways. Since SCF strongly activates phosphotidylinositol 3 kinase (PI3K) and inhibition of PI3K with LY294002 induces terminal differentiation of erythroid progenitors under Epo and SCF stimulation, SCF seems to enhance renewal divisions of erythroid progenitors via a PI3Kdependent mechanism. [Excerpt] |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/104381 |
| Appears in Collections: | Scholarly Works - FacM&SPat |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| The regulation of mRNA translation controls the balance between expansion and differentiation of erythroid progenitors 2004.pdf Restricted Access | 62.68 kB | Adobe PDF | View/Open Request a copy |
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