Decreased expression of CIP2A and SETBP1 following drug-induced activation of the PP2A complex in triple negative breast cancer cell lines

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Title:	Decreased expression of CIP2A and SETBP1 following drug-induced activation of the PP2A complex in triple negative breast cancer cell lines
Authors:	Saliba, Christian Gauci, Robert Baldacchino, Shawn Grixti, Maria Pia Scerri, Christian Grech, Godfrey
Keywords:	Triple negative breast neoplasms -- Diagnosis Breast -- Cancer -- Diagnosis Protein phosphatase 2 Phosphoprotein phosphatases -- Inhibitors Fingolimod hydrochloride
Issue Date:	2015
Publisher:	University of Malta. Medical School
Citation:	Saliba, C., Gauci, R., Baldacchino, S., Grixti, M.P., Scerri, C., & Grech, G. (2015). Decreased expression of CIP2A and SETBP1 following drug-induced activation of the PP2A complex in triple negative breast cancer cell lines. IX Malta Medical School Conference abstract book, P4.10.
Abstract:	Introduction: Triple negative breast cancer (TNBC) patients derive little benefit from target-specific therapies due to Jack of the favourable prognostic targets. Data from the cBioPortal for Cancer Genomics demonstrate that PP2A function is likely to be reduced in up to 60% of basal breast tumours. Tumours exhibit either homozygous deletion or underexpression of PP2A, but also overexpression of PP2A inhibitors namely CIP2A, SET and/or SETBP1. In this study we assess the effect of FTY720, an activator of PP2A, on breast cancer cell lines.
URI:	https://www.um.edu.mt/library/oar/handle/123456789/108852
ISSN:	18133339
Appears in Collections:	Scholarly Works - FacM&SPat

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