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https://www.um.edu.mt/library/oar/handle/123456789/108994| Title: | P010 An RNA based method to determine HER2 expression status in breast cancer patients |
| Other Titles: | An RNA based method to determine HER2 expression status in breast cancer patients |
| Authors: | Baldacchino, Shawn Sacco, Keith Saliba, Christian DeGaetano, James Scerri, Christian Grech, Godfrey |
| Keywords: | Breast -- Cancer -- Treatment Breast -- Cancer -- Immunotherapy Epidermal growth factor Genes, erbB-2 M HER-2 gene |
| Issue Date: | 2015 |
| Publisher: | Elsevier |
| Citation: | Baldacchino, S., Sacco, K., Saliba, C., DeGaetano, J., Scerri, C., & Grech, G. (2015). An RNA based method to determine HER2 expression status in Breast Cancer Patients. 14th St.Gallen International Breast Cancer Conference. The Breast, 24S1, S26-S86. |
| Abstract: | Goals: To develop an RNA based test to determine HER2 expression as part of breast cancer profiling and to compare it with the current HER2 immunohistochemistry (IHC) and FISH confirmatory techniques. Methods: A Luminex-based magnetic bead assay was designed for HER2 expression detection using fresh or Formalin-Fixed Paraffin Embedded (FFPE) tissue derived RNA. The expression value of HER2 was normalised to the geomean of a selection of housekeeping genes and statistically compared to HER2 results using conventional amplification detection methods. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/108994 |
| Appears in Collections: | Scholarly Works - FacM&SPat |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| P010 An RNA based method to determine HER2 expression status in breast cancer patients 2015.pdf Restricted Access | 69.34 kB | Adobe PDF | View/Open Request a copy |
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