Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/115306
Title: Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3) : analysis of individual data from 258 cancer registries in 61 countries
Authors: Ssenyonga, Naomi
Stiller, Charles
Nakata, Kayo
Shalkow, Jaime
Redmond, Shelagh
Bulliard, Jean-Luc
Girardi, Fabio
Fowler, Christine
Marcos-Gragera, Rafael
Bonaventure, Audrey
Saint-Jacques, Nathalie
Minicozzi, Pamela
Rodriguez-Barranco, Miguel
Laronningen, Siri
Di Carlo, Veronica
Magi, Margit
Valkov, Mikhail
Seppa, Karri
Wyn Huws, Dyfed
Coleman, Michel P.
Allemani, Claudia
Bouzbid, S.
Hamdi-Chérif, M.
Kara, L.
Meguenni, K.
Regagba, D.
Bayo, S.
Cheick Bougadari, T.
Manraj, S.S.
Bendahhou, K.
Ladipo, A.
Ogunbiyi, O. J.
Somdyala Chaplin, N. I. M.
Moreno, F.
Calabrano, G. H.
Espinola, S. B.
Carballo Quintero, B.
Fita, R.
Laspada, W. D.
Ibañez, S. G.
Lima, C. A.
Mafra Da Costa, A.
De Souza, P. C. F.
Chaves, J.
Laporte, C. A.
Curado, M. P.
de Oliveira, J. C.
Veneziano, C. L. A.
Veneziano, D. B.
Almeida, A. B. M.
Latorre, M. R. D. O.
Rebelo, M. S.
Santos, M. O.
Azevedo e Silva, G.
Galaz, J. C.
Aparicio Aravena, M.
Sanhueza Monsalve, J.
Herrmann, D. A.
Vargas, S.
Herrera, V. M.
Uribe, C. J.
Bravo, L. E.
Garcia, L. S.
Arias-Ortiz, N. E.
Morantes, D.
Jurado, D. M.
Yépez Chamorro, M. C.
Delgado, S.
Ramirez, M.
Galán Alvarez, Y. H.
Torres, P.
Martínez-Reyes, F.
Jaramillo, L.
Quinto, R.
Castillo, J.
Mendoza, M.
Cueva, P.
Yépez, J. G.
Bhakkan, B.
Deloumeaux, J.
Joachim, C.
Macni, J.
Carrillo, R.
Shalkow Klincovstein, J.
Rivera Gomez, R.
Perez, P.
Poquioma, E.
Tortolero-Luna, G.
Zavala, D.
Alonso, R.
Barrios, E.
Eckstrand, A.
Nikiforuk, C.
Woods, R. R.
Noonan, G.
Turner, D.
Kumar, E.
Zhang, B.
Dowden, J. J.
Doyle, G. P.
Saint-Jacques, N.
Walsh, G.
Anam, A.
De, P.
McClure, C. A.
Vriends, K. A.
Bertrand, C.
Ramanakumar, A. V.
Kozie, S.
Stuart-Panko, H.
Freeman, T.
George, J. T.
Avila, R. M.
O’Brien, D. K.
Holt, A.
Almon, L.
Kwong, S.
Morris, C.
Rycroft, R.
Mueller, L.
Phillips, C. E.
Brown, H.
Cromartie, B.
Ruterbusch, J.
Schwartz, A. G.
Levin, G. M.
Wohler, B.
Bayakly, R.
Ward, K. C.
Gomez, S. L.
McKinley, M.
Cress, R.
Davis, J.
Hernandez, B.
Johnson, C. J.
Morawski, B. M.
Ruppert, L. P.
Bentler, S.
Charlton, M. E.
Huang, B
TC Tucker D, T. C.
Deapen, D.
Liu, L.
Hsieh, M. C.
Wu, X. C.
Schwenn, M.
K Stern ST, K.
Gershman, S. T.
Knowlton, R. C.
Alverson, G.
Weaver, T.
Desai, J.
Rogers, D. B.
Jackson-Thompson, J.
Lemons, D.
Zimmerman, H. J.
Hood, M.
Roberts-Johnson, J.
Hammond, W.
Rees, J. R.
Pawlish, K. S.
Stroup, A.
Key, C.
Wiggins, C.
Kahn, A. R.
Schymura, M. J.
Radhakrishnan, S.
Rao, C.
Giljahn, L. K.
Slocumb, R. M.
Dabbs, C.
Espinoza, R. E.
Aird, K. G.
Beran, T.
Rubertone, J. J.
Slack, S. J.
Oh, J.
Janes, T. A.
Schwartz, S. M.
Chiodini, S. C.
Hurley, D. M.
Whiteside, M. A.
Rai, S.
Williams, M. A.
Herget, K.
Sweeney, C.
Johnson, A. T.
Keitheri Cheteri, M. B.
Migliore Santiago, P.
Blankenship, S. E.
Farley, S.
Borchers, R.
Malicki, R.
Espinoza, J.
Grandpre, J.
Weir, H. K.
Wilson, R.
Edwards, B. K.
Mariotto, A.
Wang, N.
Yang, L.
Chen, J. S.
Zhou, Y.
He, Y. T.
Song, G. H.
Gu, X. P.
Mei, D.
Mu, H. J.
Ge, H. M.
Wu, T. H.
Li, Y. Y.
Zhao, D. L.
Jin, F.
Zhang, J. H.
Zhu, F. D.
Junhua, Q.
Yang, Y. L.
Jiang, C. X.
Biao, W.
Wang, J.
Li, Q. L.
Yi, H.
Zhou, X.
Dong, J.
Li, W.
Fu, F. X.
Liu, S. Z.
Chen, J. G.
Zhu, J.
Li, Y. H.
Lu, Y. Q.
Fan, M.
Huang, S. Q.
Guo, G. P.
Zhaolai, H.
Wei, K.
Chen, W. Q.
Wei, W.
Zeng, H.
Demetriou, A. V.
Mang, W. K.
Ngan, K. C.
Kataki, A. C.
Krishnatreya, M.
Jayalekshmi, P. A.
Sebastian, P.
George, P. S.
Mathew, A.
Nandakumar, A.
Malekzadeh, R.
Roshandel, G.
Keinan-Boker, L.
Silverman, B. G.
Ito, H.
Koyanagi, Y.
Sato, M.
Tobori, F.
Nakata, I.
Teramoto, N.
Hattori, M.
Kaizaki, Y.
Moki, F.
Sugiyama, H.
Utada, M.
Nishimura, M.
Yoshida, K.
Kurosawa, K.
Nemoto, Y.
Narimatsu, H.
Sakaguchi, M.
Kanemura, S.
Naito, M.
Narisawa, R.
Miyashiro, I.
Nakata, K.
Mori, D.
Yoshitake, M.
Oki, I.
Fukushima, N.
Shibata, A.
Iwasa, K.
C Ono T O KW, C.
Matsuda, T.
Nimri, O.
Jung, K. W.
Won, Y. J.
Alawadhi, E.
Elbasmi, A.
Manan, A. Ab.
Adam, F.
Nansalmaa, E.
Tudev, U.
Ochir, C.
Khater, AM AI
Mistiri, MM EI
Lim, G. H.
Teo, Y. Y.
Chiang, C. J.
Lee, W. C.
Buasom, R.
Sangrajrang, S.
Suwanrungruang, K.
Vatanasapt, P.
Daoprasert, K.
Pongnikorn, D.
Leklob, A.
Sangkitipaiboon, S.
Geater, S. L.
Sriplung, H.
Ceylan, O.
Kög, I.
Dirican, O.
Köse, T.
Gurbuz, T.
Karaşahin, F. E.
Turhan, D.
Aktaş, U.
Halat, Y.
Eser, S.
Yakut, C. I.
Altinisik, M.
Cavusoglu, Y.
Türkköylü, A.
Üçüncü, N.
Hackl, M.
Zborovskaya, A. A.
Aleinikova, O. V.
Henau, K.
Van Eycken, L.
Atanasov, T. Y.
Valerianova, Z.
Šekerija, M.
Dušek, L.
Zvolský, M.
Steinrud Mørch, L.
Storm, H.
Wessel Skovlund, C.
Innos, K.
Mägi, M.
Malila, N.
Seppä, K.
Jégu, J.
Velten, M.
Cornet, E.
Troussard, X.
Bouvier, A. M.
Guizard, A. V.
Bouvier, V.
Launoy, G.
Dabakuyo Yonli, S.
Poillot, M. L.
Maynadié, M.
Mounier, M.
Vaconnet, L.
Woronoff, A. S.
Daoulas, M.
Robaszkiewicz, M.
Clavel, J.
Poulalhon, C.
Desandes, E.
Lacour, B.
Baldi, I.
Pouchieu, C.
Amadeo, B.
Coureau, G.
Monnereau, A.
Orazio, S.
Audoin, M.
D’Almeida, T. C.
Boyer, S.
Hammas, K.
Trétarre, B.
Colonna, M.
Delafosse, P.
Plouvier, S.
Cowppli-Bony, A.
Molinié, F.
Bara, S.
Ganry, O.
Lapôtre-Ledoux, B.
Daubisse-Marliac, L.
Bossard, L. N.
Uhry, Z.
Estève, J.
Stabenow, R.
Wilsdorf-Köhler, H.
Eberle, A.
Luttmann, S.
Löhden, I.
Nennecke, A. L.
Kieschke, J.
Sirri, E.
Justenhoven, C.
Zeissig, S. R.
Holleczek, B.
Eisemann, N.
Katalinic, A.
Asquez, R. A.
Kumar, V.
Petridou, E.
Ólafsdóttir, E. J.
Tryggvadóttir, L.
Murray, D. E.
Walsh, P. M.
Sundseth, H.
Mazzoleni, G.
Vittadello, F.
Coviello, E.
Cuccaro, F.
Galasso, R.
Sampietro, G.
Giacomin, A.
Magoni, M.
Ardizzone, A.
D’Argenzio, A.
Di Prima, A. A.
Ippolito, A.
Lavecchia, A. M.
Sutera Sardo, A.
Gola, G.
Ballotari, P.
Giacomazzi, E.
Ferretti, S.
Dal Maso, L.
Serraino, D.
Celesia, M. V.
Filiberti, R. A.
Pannozzo, F.
Melcarne, A.
Quarta, F.
Andreano, A.
Russo, A. G.
Carrozzi, G.
Cirilli, C.
Cavalieri d’Oro, L.
Rognoni, M.
Fusco, M.
Vitale, M. F.
Usala, M.
Cusimano, R.
Mazzucco, W.
Michiara, M.
Sgargi, P.
Boschetti, L.
Chiaranda, G.
Seghini, P.
Maule, M. M.
Merletti, F.
Spata, E.
Tumino, R.
Mancuso, P.
Falcini, F.
Giorgetti, S.
Caiazzo, A. L.
Cavallo, R.
Piras, D.
Bella, F.
Madeddu, A.
Fanetti, A. C.
Maspero, S.
Carone, S.
Mincuzzi, A.
Candela, G.
Scuderi, T.
Gentilini, M. A.
Rizzello, R.
Rosso, S.
Caldarella, A.
Intrieri, T.
Bianconi, F.
Contiero, P.
Tagliabue, G.
Rugge, M.
Zorzi, M.
Beggiato, S.
Brustolin, A.
Gatta, G.
De Angelis, R.
Vicentini, M.
Zanetti, R.
Stracci, F.
Maurina, A.
Oniščuka, M.
Mousavi, M.
Lipunova, N.
Vincerževskienė, I.
Agius, D.
Calleja, Neville
Siesling, S.
Visser, O.
Johannesen, T. B.
Larønningen, S.
Trojanowski, M.
Macek, P.
Mierzwa, T.
Rachtan, J.
Rosińska, A.
Kępska, K.
Kościańska, B.
Barna, K.
Sulkowska, U.
Gebauer, T.
Łapińska, J. B.
WójcikTomaszewska, J.
Motnyk, M.
Patro, A.
Gos, K.
Sikorska, K.
Bielska-Lasota, M.
Didkowska, J. A.
Wojciechowska, U.
Forjaz de Lacerda, G.
Rego, R. A.
Carrito, B.
Pais, A.
Bento, M. J.
Rodrigues, J.
Lourenço, A.
Mayer-da-Silva, A.
Blaga, L. M.
Coza, D.
Valkov, M. Y.
Gusenkova, L.
Lazarevich, O.
Prudnikova, O.
Vjushkov, D. M.
Egorova, A.
Orlov, A.
Pikalova, L. V.
Zhuikova, L. D.
Adamcik, J.
Safaei Diba, C.
Zadnik, V.
Žagar, T.
De-La-Cruz, M.
Lopez-de-Munain, A.
Aleman, A.
Rojas, D.
Chillarón, R. J.
Navarro, A. I. M.
Marcos-Gragera, R.
Puigdemont, M.
Rodríguez-Barranco, M.
Sánchez Perez, M. J.
Franch Sureda, P.
Ramos Montserrat, M.
Chirlaque López, M. D.
Sánchez Gil, A.
Ardanaz, E.
Guevara, M.
Cañete-Nieto, A.
Peris-Bonet, R.
Carulla, M.
Galceran, J.
Almela, F.
Sabater, C.
Khan, S.
Pettersson, D.
Dickman, P.
Staehelin, K.
Struchen, B.
Herrmann, C.
Egger Hayoz, C.
Bouchardy, C.
Schaffar, R.
Went, P.
Mousavi, S. M.
Bulliard, J. L.
Maspoli-Conconi, M.
Kuehni, C. E.
Redmond, S. M.
Bordoni, A.
Ortelli, L.
Chiolero, A.
Konzelmann, I.
Rohrmann, S.
Wanner, M.
Broggio, J.
Rashbass, J.
Stiller, C.
Fitzpatrick, D.
Gavin, A.
Morrison, D. S.
Thomson, C. S.
Greene, G.
Huws, D. W.
Allemani, C.
Coleman, M. P.
Di Carlo, V.
Girardi, F.
Matz, M.
Minicozzi, P.
Sanz, N.
Ssenyonga, N.
Stephens, R.
Chalker, E.
Smith, M.
Gugusheff, J.
You, H.
Qin Li, S.
Dugdale, S.
Moore, J.
Philpot, S.
Pfeiffer, R.
Thomas, H.
Silva Ragaini, B.
Venn, A. J.
Evans, S. M.
Te Marvelde, L.
Savietto, V.
Trevithick, R.
Currow, D.
Fowler, C.
Lewis, C.
Authors: CONCORD Working Group
Keywords: Leukemia
Cancer in children
Cancer in adolescence
Leukemia in children
Issue Date: 2022
Publisher: The Lancet Publishing Group
Citation: Ssenyonga, N., Stiller, C., Nakata, K., Shalkow, J., Redmond, S., Bulliard, J. L., ... & Alverson, G. (2022). Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3): analysis of individual data from 258 cancer registries in 61 countries. The lancet child & adolescent health, 6(6), 409-431.
Abstract: Background Leukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0–14 years) and adults (aged 15–99 years) diagnosed with a haematological malignancy during 2000–14 in 61 countries. Here, we aimed to examine worldwide trends in survival from leukaemia, by age and morphology, in young patients (aged 0–24 years). Methods We analysed data from 258 population-based cancer registries in 61 countries participating in CONCORD-3 that submitted data on patients diagnosed with leukaemia. We grouped patients by age as children (0–14 years), adolescents (15–19 years), and young adults (20–24 years). We categorised leukaemia subtypes according to the International Classification of Childhood Cancer (ICCC-3), updated with International Classification of Diseases for Oncology, third edition (ICD-O-3) codes. We estimated 5-year net survival by age and morphology, with 95% CIs, using the non-parametric Pohar-Perme estimator. To control for background mortality, we used life tables by country or region, single year of age, single calendar year and sex, and, where possible, by race or ethnicity. All-age survival estimates were standardised to the marginal distribution of young people with leukaemia included in the analysis. Findings 164563 young people were included in this analysis: 121328 (73·7%) children, 22963 (14·0%) adolescents, and 20272 (12·3%) young adults. In 2010–14, the most common subtypes were lymphoid leukaemia (28205 [68·2%] patients) and acute myeloid leukaemia (7863 [19·0%] patients). Age-standardised 5-year net survival in children, adolescents, and young adults for all leukaemias combined during 2010–14 varied widely, ranging from 46% in Mexico to more than 85% in Canada, Cyprus, Belgium, Denmark, Finland, and Australia. Individuals with lymphoid leukaemia had better age-standardised survival (from 43% in Ecuador to ≥80% in parts of Europe, North America, Oceania, and Asia) than those with acute myeloid leukaemia (from 32% in Peru to ≥70% in most high-income countries in Europe, North America, and Oceania). Throughout 2000–14, survival from all leukaemias combined remained consistently higher for children than adolescents and young adults, and minimal improvement was seen for adolescents and young adults in most countries. Interpretation This study offers the first worldwide picture of population-based survival from leukaemia in children, adolescents, and young adults. Adolescents and young adults diagnosed with leukaemia continue to have lower survival than children. Trends in survival from leukaemia for adolescents and young adults are important indicators of the quality of cancer management in this age group.
URI: https://www.um.edu.mt/library/oar/handle/123456789/115306
Appears in Collections:Scholarly Works - FacM&SPH



Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.