Mismatch repair protein expression defects in endometrioid endometrial adenocarcinoma

Abstract

Introduction/Background Endometrial cancer has been shown to be the sentinel cancer in over half the female patients with heritable mismatch repair (MMR) mutations as part of Lynch syndrome. Immunohistochemical testing for MMR protein expression in endometrial cancer is the first screening test identifying cases that potentially harbour familial cancer syndrome-related mutations. MMR has also become a biomarker to predict response to targeted therapeutics such as in immune-checkpoint blockade. This is the first study to describe the prevalence of MMR protein expression defects in Maltese endometrial carcinoma patients and the correlation with patient age at diagnosis.