Burkitt’s Lymphoma in 3 years-old boy with craniofacial presentation

Abstract

BACKGROUND: Burkitt’s lymphoma (BL) is an aggressive non-Hodgkin B-cell lymphoma with rapid growth. The majority of endemic BL occurs in children aged 5-12 years old with mandibular involvement.

CASE: We presented a rare case of BL in 3 years-old boy with craniofacial involvement in Indonesia. A boy came to the emergency department with a massive mass in the upper-left facial area. The mass was 10 x 5 x 5 cm with eye and maxillary infiltration. Three months before, the patient came to the outpatient clinic with a slightly-visible and painless mass in the left cheek without any lymph node enlargement. The blood examination revealed no abnormalities, yet the LDH level was 1.260 U/L. The histopathological examination supported the diagnosis of Burkitt’s lymphoma. No leukemic cells or metastases were found in bone marrow aspiration. The patient received Cyclophosphamide, Vincristine, Methotrexate, and oral prednisone. The patient responded well and the mass was completely resolved in 3 weeks with no complications.