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https://www.um.edu.mt/library/oar/handle/123456789/139385| Title: | Drug design and optimisation at the dihydroorotate dehydrogenase (DHODH) receptor using the teriflunomide scaffold as a lead |
| Authors: | Zammit, Paula Shoemake, Claire |
| Keywords: | Drugs -- Design Pharmaceutical chemistry Dihydroorotate dehydrogenase -- Inhibitors Enzyme inhibitors Epilepsy -- Chemotherapy |
| Issue Date: | 2025 |
| Publisher: | University of Malta. Department of Pharmacy |
| Citation: | Zammit, P., & Shoemake, C. (2025). Drug design and optimisation at the dihydroorotate dehydrogenase (DHODH) receptor using the teriflunomide scaffold as a lead. Poster session presented at the 83rd FIP World Congress of Pharmacy and Pharmaceutical Sciences, Copenhagen. |
| Abstract: | Introduction: Mouse studies show that DHODH inhibition is a novel route for the
treatment of epilepsy. Teriflunomide has been identified as a potent
DHODH inhibitor with poor intra-cerebral penetration due to high polarity. Aims: To use the teriflunomide scaffold to identify DHODH inhibitors with improved non-polar characteristics, predisposing to better intracerebral penetration, by means of virtual screening and de novo drug design. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/139385 |
| Appears in Collections: | Scholarly Works - FacM&SPha |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Drug design and optimisation at the dihydroorotate dehydrogenase DHODH receptor using the teriflunomide scaffold as a lead 2025.pdf | 396.62 kB | Adobe PDF | View/Open |
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