Process development of non-ionizing, microbial remediation for medicinal cannabis flower

Abstract

Introduction: The compact morphology and dense flower structure of cannabis make it more susceptible to microbial contamination, increasing difficulty in microbial control during cultivation and production Microbial proliferation can lead to product losses and pose health risks, particularly to immunocompromised patients While ionising irradiation is commonly used, non irradiated product is preferred in some countries such as Germany Advanced oxidation technologies, can alternatively be used to reduce microbial levels by disrupting microbial cell integrity

Aims: • To plan and design a suitable approach for microbial remediation of medicinal cannabis flower using quality and risk management tools, ensuring regulatory compliance and product quality preservation • To establish the critical process parameters and define a process validation protocol in line with EU GMP for the proposed microbial remediation method.