Cholecystokinin as a novel marker of gallstones risk factor

Abstract

INTRODUCTION: cholecystokinin plays a role role in both the regulation of digestion and appetite as well as its association with the development and management of gallstones.

OBJECTIVE: The study aimed to investigate the relationship between the cholecystokinin hormone and the formation of gallstones.

METHODS: The study collected a total of 97 samples of gallstones from both sexes, with an additional 83 samples used as a control group.

RESULTS: There was a significant (p= 0.001) decrease in the cholecystokinin hormone levels in patients with gallstones. Furthermore, the study also observed a significant increase (p= 0.001) in various lipid markers such as cholesterol, low-density lipoprotein (LDL), triglycerides, lipoprotein, very low-density lipoprotein (VLDL), and atherosclerosis risk factor. The incidence of gallstones was found to be three times higher in females compared to males.

CONCLUSION: This study shed light on the role of the cholecystokinin hormone in the formation of gallstones. It revealed a significant decrease in cholecystokinin hormone levels in patients with gallstones, along with an increase in lipid markers associated with gallstone formation. Additionally, the study highlighted the gender disparity in the incidence of gallstones and provided reference ranges for the cholecystokinin hormone. These findings have the potential to contribute to the development of new diagnostic and treatment approaches for gallstone-related conditions.