Recurrence rate and prognostic factors in laparoscopically resected colorectal malignancies

Abstract

BACKGROUND: There are limited data on the 2-year recurrence rate and prognostic factors for recurrence in laparoscopically resected colorectal malignancies. The aim of this study was to determine the 2-year recurrence rate and prognostic factors for recurrence of colorectal carcinoma in patients who underwent elective laparoscopic colectomy.

METHODS: Data from patients with colorectal carcinoma who had undergone elective laparoscopic colectomy in HPUSM were retrospectively reviewed. All patients who had a follow-up of at least 24 months and traceable records were included in the study, whereas patients with concurrent pathologies were excluded. Patients' clinicopathologic data and follow-up data for 2 years after surgery were examined. Cox proportional hazard regression was used to determine the possible prognostic factors for colorectal cancer recurrence.

RESULTS: Of 40 patients, five patients had recurrence within 2 years after surgery, representing a recurrence rate of 12.5%. The average time to recurrence was 21.2 months, with the earliest recurrence occurring on the 15th day after surgery. Postoperative serum level of carcinoembryonic antigen (CEA) was the prognostic factor for colorectal cancer recurrence [hazard ratio (HR): 1.05, 95% CI: 1.00, 1.10, p = 0.04].

CONCLUSION: The results of our study showed that the 2-year recurrence rate in this study setting was 12.5%. The significant prognostic factor for recurrence of colorectal cancer in patients who underwent elective laparoscopic colectomy was postoperative CEA levels.