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Title: Pharmacogenetics : the science of predictive clinical pharmacology
Authors: Fenech, Anthony G.
Grech, Godfrey
Keywords: Pharmacogenetics
Drugs -- Testing
Clinical pharmacology
Issue Date: 2014
Publisher: Malta Chamber of Scientists
Citation: Xjenza. 2014, Vol.2(1), p. 14-31
Abstract: The study of pharmacogenetics has expanded from what were initially casual family-based clinical drug response observations, to a fully-fledged science with direct therapeutic applications, all within a time-span of less than 60 years. A wide spectrum of polymorphisms, located within several genes, are now recognised to influence the pharmacokinetics and pharmacodynamics of the majority of drugs within our therapeutic armamentarium. This information forms the basis for the new development of pharmacogenetic genotyping tests, which can be used to predict the therapeutic and/or adverse effects of a specific drug in a particular patient. Pharmacogenetic-guided, patient targeted therapy has now become the developing fulcrum of personalized medicine, as it provides the best means to optimize benefit/risk ratio in pharmacological management.
Appears in Collections:Xjenza, 2014, Volume 2, Issue 1
Xjenza, 2014, Volume 2, Issue 1

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