Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/22759
Title: Acute administration of amitriptyline and mianserin increases dopamine release in the rat nucleus accumbens : possible involvement of serotonin2C receptors
Authors: Matteo, Vincenzo di
Mascio, Michele di
Di Giovanni, Giuseppe
Esposito, Ennio
Keywords: Dopamine
Microdialysis
Amitriptyline
Mianserin
Nucleus accumbens
Issue Date: 2000
Publisher: Springer
Citation: Di Matteo, V., Di Mascio, M., Di Giovanni, G., & Esposito,E. (2000). Acute administration of amitriptyline and mianserin increases dopamine release in the rat nucleus accumbens : possible involvement of serotonin2C receptors. Psychopharmacology, 150(1), 45-51.
Abstract: Previous studies of conventional tricyclic and non-tricyclic antidepressants have suggested that a number of these drugs display considerable pharmacological activity at 5-HT2C receptors in the brain. There is evidence that 5-HT2C receptors are involved in the control of the activity of the central dopaminergic system. Therefore, the effects of amitriptyline (5 mg/kg and 10 mg/kg i.p.) and of the atypical antidepressant mianserin (2.5 mg/kg and 5 mg/kg i.p.) were studied on the extracellular concentration of dopamine (DA) in the nucleus accumbens of chloral hydrate-anesthetized rats, using intracerebral microdialysis. Amitriptyline and mianserin significantly increased DA release (+31.1±7.9% and +33.6±4.3%, respectively) at the higher doses. In addition, lower doses of mianserin (2.5 mg/kg i.p.) and amitriptyline (5 mg/kg i.p.) blocked the inhibitory action of RO 60-0175 (1 mg/kg i.p.), a selective 5-HT2C receptor agonist, on DA release. The effect of RO 60-0175 (1 mg/kg i.p.) was completely blocked by SB 242084 (2.5 mg/kg i.p.), a selective and powerful 5-HT2C receptor antagonist. Taken together, these data indicate that amitriptyline and mianserin increase DA release in the nucleus accumbens by blocking 5-HT2C receptors.
URI: https://www.um.edu.mt/library/oar//handle/123456789/22759
Appears in Collections:Scholarly Works - FacM&SPB

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