Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/22775
Title: Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin2C receptors
Authors: Matteo, Vincenzo di
Di Giovanni, Giuseppe
Mascio, Michele di
Esposito, Ennio
Keywords: Brain microdialysis
Receptor, Serotonin, 5-HT2C
Electrophysiology
Serotonin
Issue Date: 2000
Publisher: Elsevier BV
Citation: Di Matteo, V., Di Giovanni, G., Di Mascio, M., & Esposito, E. (2000). Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin2C receptors. Brain Research, 865(1), 85-90.
Abstract: In vivo microdialysis and electrophysiological techniques were used to elucidate the role of the 5-HT2 receptor family on the control of mesolimbic dopaminergic system exerted by serotonin (5-HT). Administration of RO 60-0175 (1 mg/kg, i.p.), a selective 5-HT2C receptor agonist, significantly decreased dopamine (DA) release by 26±4% (below baseline) 60 min after injection. Moreover, RO 60-0175 (80–320 μg/kg, i.v.) dose-dependently decreased the basal firing rate of DA neurons in the ventral tegmental area (VTA), reaching its maximal inhibitory effect (53.9±15%, below baseline) after the dose of 320 μg/kg. The selective 5-HT2C receptor antagonist SB 242084 completely blocked the inhibitory action of RO 60-0175 on accumbal DA release and on the firing rate of VTA DA cells. On the contrary, both (±)-DOI, a mixed 5-HT2A/2C receptor agonist, and the selective 5-HT2B agonist BW 723C86, did not affect either DA release in the nucleus accumbens or the firing rate of VTA DA cells. Taken together, these data confirm that central 5-HT system exerts an inhibitory control on the mesolimbic DA system and that 5-HT2C receptors are involved in this effect.
URI: https://www.um.edu.mt/library/oar//handle/123456789/22775
Appears in Collections:Scholarly Works - FacM&SPB

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